Imaging application of an MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe
In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our research group has synthesized a kind of nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which has the characteristic of matrix metalloproteinase-2 (MMP2) sensitive ability in tumor microenvironment. Meanwhile, the encapsulation method is adopted to prepare MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe with mPEG2000-GPLGIAGQ-DSPE as the carrier. On the one hand, this novel nanoprobe not only can effectively improve the solubility of prussian blue, but is non-toxic and safe for cells. On the other hand, octapeptide (GPLGIAGQ) in mPEG2000-GPLGIAGQ-DSPE nanocarrier can specifically respond to MMP2 in tumor cells to release prussian blue, and achieve targeted intelligent imaging of tumor cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Journal of biomaterials applications - 38(2023), 3 vom: 16. Sept., Seite 372-380 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhou, Xinglu [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.09.2023 Date Revised 14.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/08853282231194147 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM360309445 |
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| 245 | 1 | 0 | |a Imaging application of an MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe |
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| 500 | |a Date Revised 14.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our research group has synthesized a kind of nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which has the characteristic of matrix metalloproteinase-2 (MMP2) sensitive ability in tumor microenvironment. Meanwhile, the encapsulation method is adopted to prepare MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe with mPEG2000-GPLGIAGQ-DSPE as the carrier. On the one hand, this novel nanoprobe not only can effectively improve the solubility of prussian blue, but is non-toxic and safe for cells. On the other hand, octapeptide (GPLGIAGQ) in mPEG2000-GPLGIAGQ-DSPE nanocarrier can specifically respond to MMP2 in tumor cells to release prussian blue, and achieve targeted intelligent imaging of tumor cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Imaging | |
| 650 | 4 | |a MMP2 | |
| 650 | 4 | |a fluorescent nanoprobe | |
| 650 | 4 | |a prussian blue | |
| 650 | 4 | |a tumor | |
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| 700 | 1 | |a Zhang, Changmei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Qiquan |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaoyan |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Yujie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Jingna |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Lei |e verfasserin |4 aut | |
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