Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort
© 2023. The Author(s)..
PURPOSE: In this study, we explore the relationship between social jetlag (SJL), a parameter of circadian misalignment, and gut microbial composition, diet and cardiometabolic health in the ZOE PREDICT 1 cohort (NCT03479866).
METHODS: We assessed demographic, diet, cardiometabolic, stool metagenomics and postprandial metabolic measures (n = 1002). We used self-reported habitual sleep (n = 934) to calculate SJL (difference in mid-sleep time point of ≥ 1.5 h on week versus weekend days). We tested group differences (SJL vs no-SJL) in cardiometabolic markers and diet (ANCOVA) adjusting for sex, age, BMI, ethnicity, and socio-economic status. We performed comparisons of gut microbial composition using machine learning and association analyses on the species level genome bins present in at least 20% of the samples.
RESULTS: The SJL group (16%, n = 145) had a greater proportion of males (39% vs 25%), shorter sleepers (average sleep < 7 h; 5% vs 3%), and were younger (38.4 ± 11.3y vs 46.8 ± 11.7y) compared to the no-SJL group. SJL was associated with a higher relative abundance of 9 gut bacteria and lower abundance of 8 gut bacteria (q < 0.2 and absolute Cohen's effect size > 0.2), in part mediated by diet. SJL was associated with unfavourable diet quality (less healthful Plant-based Diet Index), higher intakes of potatoes and sugar-sweetened beverages, and lower intakes of fruits, and nuts, and slightly higher markers of inflammation (GlycA and IL-6) compared with no-SJL (P < 0.05 adjusted for covariates); rendered non-significant after multiple testing adjustments.
CONCLUSIONS: Novel associations between SJL and a more disadvantageous gut microbiome in a cohort of predominantly adequate sleepers highlight the potential implications of SJL for health.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
European journal of nutrition - 62(2023), 8 vom: 01. Dez., Seite 3135-3147 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bermingham, Kate M [VerfasserIn] |
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| Links: |
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| Themen: |
Clinical Study |
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| Anmerkungen: |
Date Completed 31.10.2023 Date Revised 28.02.2024 published: Print-Electronic ClinicalTrials.gov: NCT03479866 Citation Status MEDLINE |
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| doi: |
10.1007/s00394-023-03204-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Bermingham, Kate M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 31.10.2023 | ||
| 500 | |a Date Revised 28.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT03479866 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: In this study, we explore the relationship between social jetlag (SJL), a parameter of circadian misalignment, and gut microbial composition, diet and cardiometabolic health in the ZOE PREDICT 1 cohort (NCT03479866) | ||
| 520 | |a METHODS: We assessed demographic, diet, cardiometabolic, stool metagenomics and postprandial metabolic measures (n = 1002). We used self-reported habitual sleep (n = 934) to calculate SJL (difference in mid-sleep time point of ≥ 1.5 h on week versus weekend days). We tested group differences (SJL vs no-SJL) in cardiometabolic markers and diet (ANCOVA) adjusting for sex, age, BMI, ethnicity, and socio-economic status. We performed comparisons of gut microbial composition using machine learning and association analyses on the species level genome bins present in at least 20% of the samples | ||
| 520 | |a RESULTS: The SJL group (16%, n = 145) had a greater proportion of males (39% vs 25%), shorter sleepers (average sleep < 7 h; 5% vs 3%), and were younger (38.4 ± 11.3y vs 46.8 ± 11.7y) compared to the no-SJL group. SJL was associated with a higher relative abundance of 9 gut bacteria and lower abundance of 8 gut bacteria (q < 0.2 and absolute Cohen's effect size > 0.2), in part mediated by diet. SJL was associated with unfavourable diet quality (less healthful Plant-based Diet Index), higher intakes of potatoes and sugar-sweetened beverages, and lower intakes of fruits, and nuts, and slightly higher markers of inflammation (GlycA and IL-6) compared with no-SJL (P < 0.05 adjusted for covariates); rendered non-significant after multiple testing adjustments | ||
| 520 | |a CONCLUSIONS: Novel associations between SJL and a more disadvantageous gut microbiome in a cohort of predominantly adequate sleepers highlight the potential implications of SJL for health | ||
| 650 | 4 | |a Clinical Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Diet | |
| 650 | 4 | |a Gut microbiome | |
| 650 | 4 | |a Social jetlag | |
| 700 | 1 | |a Stensrud, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Asnicar, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Valdes, Ana M |e verfasserin |4 aut | |
| 700 | 1 | |a Franks, Paul W |e verfasserin |4 aut | |
| 700 | 1 | |a Wolf, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Hadjigeorgiou, George |e verfasserin |4 aut | |
| 700 | 1 | |a Davies, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Spector, Tim D |e verfasserin |4 aut | |
| 700 | 1 | |a Segata, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Berry, Sarah E |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Wendy L |e verfasserin |4 aut | |
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