Acoustic-electric trigeminal-nerve stimulation enhances functional connectivity in patients with disorders of consciousness
© 2023 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd..
AIM: Disruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoustic-electric trigeminal-nerve stimulation (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) in the gamma band can improve consciousness in patients with DOC. Here, we investigated whether these beneficial stimulation effects are mediated by alterations in functional connectivity.
METHODS: Sixty-three patients with DOC underwent 5 days of gamma, beta, or sham acoustic-electric trigeminal-nerve stimulation. Resting-state electroencephalography was measured before and after the stimulation and functional connectivity was assessed using phase-lag index (PLI).
RESULTS: We found that gamma stimulation induces an increase in gamma-band PLI. Further characterization revealed that the enhancing effect is (i) specific to the gamma band (as we observed no comparable change in beta-band PLI and no effect of beta-band acoustic-electric stimulation or sham stimulation), (ii) widely spread across the cortex, and (iii) accompanied by improvements in patients' auditory abilities.
CONCLUSION: These findings show that gamma acoustic-electric trigeminal-nerve stimulation can improve resting-state functional connectivity in the gamma band, which in turn may be linked to auditory abilities and/or consciousness restoration in DOC patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
CNS neuroscience & therapeutics - 30(2024), 3 vom: 01. März, Seite e14385 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Min [VerfasserIn] |
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| Links: |
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| Themen: |
Acoustic stimulation |
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| Anmerkungen: |
Date Completed 13.03.2024 Date Revised 18.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/cns.14385 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM360252664 |
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| 245 | 1 | 0 | |a Acoustic-electric trigeminal-nerve stimulation enhances functional connectivity in patients with disorders of consciousness |
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| 500 | |a Date Completed 13.03.2024 | ||
| 500 | |a Date Revised 18.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. | ||
| 520 | |a AIM: Disruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoustic-electric trigeminal-nerve stimulation (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) in the gamma band can improve consciousness in patients with DOC. Here, we investigated whether these beneficial stimulation effects are mediated by alterations in functional connectivity | ||
| 520 | |a METHODS: Sixty-three patients with DOC underwent 5 days of gamma, beta, or sham acoustic-electric trigeminal-nerve stimulation. Resting-state electroencephalography was measured before and after the stimulation and functional connectivity was assessed using phase-lag index (PLI) | ||
| 520 | |a RESULTS: We found that gamma stimulation induces an increase in gamma-band PLI. Further characterization revealed that the enhancing effect is (i) specific to the gamma band (as we observed no comparable change in beta-band PLI and no effect of beta-band acoustic-electric stimulation or sham stimulation), (ii) widely spread across the cortex, and (iii) accompanied by improvements in patients' auditory abilities | ||
| 520 | |a CONCLUSION: These findings show that gamma acoustic-electric trigeminal-nerve stimulation can improve resting-state functional connectivity in the gamma band, which in turn may be linked to auditory abilities and/or consciousness restoration in DOC patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a acoustic stimulation | |
| 650 | 4 | |a disorders of consciousness | |
| 650 | 4 | |a electric trigeminal-nerve stimulation | |
| 650 | 4 | |a gamma band | |
| 650 | 4 | |a resting-state functional connectivity | |
| 700 | 1 | |a Concolato, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Sorger, Bettina |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Yamei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaoxia |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Benyan |e verfasserin |4 aut | |
| 700 | 1 | |a Riecke, Lars |e verfasserin |4 aut | |
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