TMEM175 : A lysosomal ion channel associated with neurological diseases
Copyright © 2023. Published by Elsevier Inc..
Lysosomes are acidic intracellular organelles with autophagic functions that are critical for protein degradation and mitochondrial homeostasis, while abnormalities in lysosomal physiological functions are closely associated with neurological disorders. Transmembrane protein 175 (TMEM175), an ion channel in the lysosomal membrane that is essential for maintaining lysosomal acidity, has been proven to coordinate with V-ATPase to modulate the luminal pH of the lysosome to assist the digestion of abnormal proteins and organelles. However, there is considerable controversy about the characteristics of TMEM175. In this review, we introduce the research progress on the structural, modulatory, and functional properties of TMEM175, followed by evidence of its relevance for neurological disorders. Finally, we discuss the potential value of TMEM175 as a therapeutic target in the hope of providing new directions for the treatment of neurodegenerative diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:185 |
|---|---|
| Enthalten in: |
Neurobiology of disease - 185(2023) vom: 13. Sept., Seite 106244 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wu, Luojia [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Autophagy |
|---|
| Anmerkungen: |
Date Completed 04.09.2023 Date Revised 02.10.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.nbd.2023.106244 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM360240380 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM360240380 | ||
| 003 | DE-627 | ||
| 005 | 20231226082607.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.nbd.2023.106244 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1200.xml |
| 035 | |a (DE-627)NLM360240380 | ||
| 035 | |a (NLM)37524211 | ||
| 035 | |a (PII)S0969-9961(23)00259-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wu, Luojia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a TMEM175 |b A lysosomal ion channel associated with neurological diseases |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.09.2023 | ||
| 500 | |a Date Revised 02.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier Inc. | ||
| 520 | |a Lysosomes are acidic intracellular organelles with autophagic functions that are critical for protein degradation and mitochondrial homeostasis, while abnormalities in lysosomal physiological functions are closely associated with neurological disorders. Transmembrane protein 175 (TMEM175), an ion channel in the lysosomal membrane that is essential for maintaining lysosomal acidity, has been proven to coordinate with V-ATPase to modulate the luminal pH of the lysosome to assist the digestion of abnormal proteins and organelles. However, there is considerable controversy about the characteristics of TMEM175. In this review, we introduce the research progress on the structural, modulatory, and functional properties of TMEM175, followed by evidence of its relevance for neurological disorders. Finally, we discuss the potential value of TMEM175 as a therapeutic target in the hope of providing new directions for the treatment of neurodegenerative diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Autophagy | |
| 650 | 4 | |a Ion channel | |
| 650 | 4 | |a Lysosomal membrane protein | |
| 650 | 4 | |a Lysosome | |
| 650 | 4 | |a Neurological disease | |
| 650 | 4 | |a TMEM175 | |
| 650 | 7 | |a Ion Channels |2 NLM | |
| 650 | 7 | |a TMEM175 protein, human |2 NLM | |
| 650 | 7 | |a Potassium Channels |2 NLM | |
| 700 | 1 | |a Lin, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Jiali |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Longshan |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Xiuqin |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Gen |e verfasserin |4 aut | |
| 700 | 1 | |a Hua, Fuzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Ying, Jun |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurobiology of disease |d 1997 |g 185(2023) vom: 13. Sept., Seite 106244 |w (DE-627)NLM089461223 |x 1095-953X |7 nnns |
| 773 | 1 | 8 | |g volume:185 |g year:2023 |g day:13 |g month:09 |g pages:106244 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.nbd.2023.106244 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 185 |j 2023 |b 13 |c 09 |h 106244 | ||