Vaginal morphology and position associated with prolapse recurrence after vaginal surgery : A secondary analysis of the DEMAND study
© 2023 John Wiley & Sons Ltd..
OBJECTIVE: To identify vaginal morphology and position factors associated with prolapse recurrence following vaginal surgery.
DESIGN: Secondary analysis of magnetic resonance images (MRI) of the Defining Mechanisms of Anterior Vaginal Wall Descent cross-sectional study.
SETTING: Eight clinical sites in the US Pelvic Floor Disorders Network.
POPULATION OR SAMPLE: Women who underwent vaginal mesh hysteropexy (hysteropexy) with sacrospinous fixation or vaginal hysterectomy with uterosacral ligament suspension (hysterectomy) for uterovaginal prolapse between April 2013 and February 2015.
METHODS: The MRI (rest, strain) obtained 30-42 months after surgery, or earlier for participants with recurrence who desired reoperation before 30 months, were analysed. MRI-based prolapse recurrence was defined as prolapse beyond the hymen at strain on MRI. Vaginal segmentations (at rest) were used to create three-dimensional models placed in a morphometry algorithm to quantify and compare vaginal morphology (angulation, dimensions) and position.
MAIN OUTCOME MEASURES: Vaginal angulation (upper, lower and upper-lower vaginal angles in the sagittal and coronal plane), dimensions (length, maximum transverse width, surface area, volume) and position (apex, mid-vagina) at rest.
RESULTS: Of the 82 women analysed, 12/41 (29%) in the hysteropexy group and 22/41 (54%) in the hysterectomy group had prolapse recurrence. After hysteropexy, women with recurrence had a more laterally deviated upper vagina (p = 0.02) at rest than women with successful surgery. After hysterectomy, women with recurrence had a more inferiorly (lower) positioned vaginal apex (p = 0.01) and mid-vagina (p = 0.01) at rest than women with successful surgery.
CONCLUSIONS: Vaginal angulation and position were associated with prolapse recurrence and suggestive of vaginal support mechanisms related to surgical technique and potential unaddressed anatomical defects. Future prospective studies in women before and after prolapse surgery may distinguish these two factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:131 |
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| Enthalten in: |
BJOG : an international journal of obstetrics and gynaecology - 131(2024), 3 vom: 23. Feb., Seite 267-277 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bowen, Shaniel T [VerfasserIn] |
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| Links: |
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| Themen: |
Angulation |
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| Anmerkungen: |
Date Completed 15.01.2024 Date Revised 23.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1471-0528.17620 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360220991 |
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| 041 | |a eng | ||
| 100 | 1 | |a Bowen, Shaniel T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vaginal morphology and position associated with prolapse recurrence after vaginal surgery |b A secondary analysis of the DEMAND study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.01.2024 | ||
| 500 | |a Date Revised 23.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: To identify vaginal morphology and position factors associated with prolapse recurrence following vaginal surgery | ||
| 520 | |a DESIGN: Secondary analysis of magnetic resonance images (MRI) of the Defining Mechanisms of Anterior Vaginal Wall Descent cross-sectional study | ||
| 520 | |a SETTING: Eight clinical sites in the US Pelvic Floor Disorders Network | ||
| 520 | |a POPULATION OR SAMPLE: Women who underwent vaginal mesh hysteropexy (hysteropexy) with sacrospinous fixation or vaginal hysterectomy with uterosacral ligament suspension (hysterectomy) for uterovaginal prolapse between April 2013 and February 2015 | ||
| 520 | |a METHODS: The MRI (rest, strain) obtained 30-42 months after surgery, or earlier for participants with recurrence who desired reoperation before 30 months, were analysed. MRI-based prolapse recurrence was defined as prolapse beyond the hymen at strain on MRI. Vaginal segmentations (at rest) were used to create three-dimensional models placed in a morphometry algorithm to quantify and compare vaginal morphology (angulation, dimensions) and position | ||
| 520 | |a MAIN OUTCOME MEASURES: Vaginal angulation (upper, lower and upper-lower vaginal angles in the sagittal and coronal plane), dimensions (length, maximum transverse width, surface area, volume) and position (apex, mid-vagina) at rest | ||
| 520 | |a RESULTS: Of the 82 women analysed, 12/41 (29%) in the hysteropexy group and 22/41 (54%) in the hysterectomy group had prolapse recurrence. After hysteropexy, women with recurrence had a more laterally deviated upper vagina (p = 0.02) at rest than women with successful surgery. After hysterectomy, women with recurrence had a more inferiorly (lower) positioned vaginal apex (p = 0.01) and mid-vagina (p = 0.01) at rest than women with successful surgery | ||
| 520 | |a CONCLUSIONS: Vaginal angulation and position were associated with prolapse recurrence and suggestive of vaginal support mechanisms related to surgical technique and potential unaddressed anatomical defects. Future prospective studies in women before and after prolapse surgery may distinguish these two factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a angulation | |
| 650 | 4 | |a dimension | |
| 650 | 4 | |a hysterectomy | |
| 650 | 4 | |a hysteropexy | |
| 650 | 4 | |a pelvic organ prolapse | |
| 650 | 4 | |a position | |
| 650 | 4 | |a prolapse recurrence | |
| 650 | 4 | |a vagina | |
| 650 | 4 | |a vaginal mesh | |
| 700 | 1 | |a Moalli, Pamela A |e verfasserin |4 aut | |
| 700 | 1 | |a Abramowitch, Steven D |e verfasserin |4 aut | |
| 700 | 1 | |a Luchristt, Douglas H |e verfasserin |4 aut | |
| 700 | 1 | |a Meyer, Isuzu |e verfasserin |4 aut | |
| 700 | 1 | |a Rardin, Charles R |e verfasserin |4 aut | |
| 700 | 1 | |a Harvie, Heidi S |e verfasserin |4 aut | |
| 700 | 1 | |a Hahn, Michael E |e verfasserin |4 aut | |
| 700 | 1 | |a Mazloomdoost, Donna |e verfasserin |4 aut | |
| 700 | 1 | |a Iyer, Pooja |e verfasserin |4 aut | |
| 700 | 1 | |a Carper, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Gantz, Marie G |e verfasserin |4 aut | |
| 700 | 0 | |a NICHD Pelvic Floor Disorders Network |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrante, Kimberly |e investigator |4 oth | |
| 700 | 1 | |a Johnson, Sherella |e investigator |4 oth | |
| 700 | 1 | |a Lukacz, Emily S |e investigator |4 oth | |
| 700 | 1 | |a Nager, Charles W |e investigator |4 oth | |
| 700 | 1 | |a Diwadkar, Gouri B |e investigator |4 oth | |
| 700 | 1 | |a Dyer, Keisha Y |e investigator |4 oth | |
| 700 | 1 | |a Mackinnon, Linda M |e investigator |4 oth | |
| 700 | 1 | |a Tan-Kim, Jasmine |e investigator |4 oth | |
| 700 | 1 | |a Zazueta-Damian, Gisselle |e investigator |4 oth | |
| 700 | 1 | |a Amundsen, Cindy |e investigator |4 oth | |
| 700 | 1 | |a Bruton, Yasmeen |e investigator |4 oth | |
| 700 | 1 | |a Coleman-Taylor, Notorious |e investigator |4 oth | |
| 700 | 1 | |a Kawasaki, Amie |e investigator |4 oth | |
| 700 | 1 | |a McLean, Shantae |e investigator |4 oth | |
| 700 | 1 | |a Siddiqui, Nazema |e investigator |4 oth | |
| 700 | 1 | |a Weidner, Alison |e investigator |4 oth | |
| 700 | 1 | |a Carter, Kathy |e investigator |4 oth | |
| 700 | 1 | |a Ellington, David |e investigator |4 oth | |
| 700 | 1 | |a Lockhart, Mark E |e investigator |4 oth | |
| 700 | 1 | |a Patel, Sunita |e investigator |4 oth | |
| 700 | 1 | |a Richter, Holly E |e investigator |4 oth | |
| 700 | 1 | |a Saxon, Nancy |e investigator |4 oth | |
| 700 | 1 | |a Willis, Velria B |e investigator |4 oth | |
| 700 | 1 | |a Carberry, Cassandra |e investigator |4 oth | |
| 700 | 1 | |a Hampton, B Star |e investigator |4 oth | |
| 700 | 1 | |a Korbly, Nicole |e investigator |4 oth | |
| 700 | 1 | |a Meers, Ann S |e investigator |4 oth | |
| 700 | 1 | |a Myers, Deborah L |e investigator |4 oth | |
| 700 | 1 | |a Sung, Vivian W |e investigator |4 oth | |
| 700 | 1 | |a Viscione, Elizabeth-Ann |e investigator |4 oth | |
| 700 | 1 | |a Wohlrab, Kyle |e investigator |4 oth | |
| 700 | 1 | |a Dunivan, Gena |e investigator |4 oth | |
| 700 | 1 | |a Komesu, Yuko |e investigator |4 oth | |
| 700 | 1 | |a Jeppson, Peter |e investigator |4 oth | |
| 700 | 1 | |a Arya, Lily |e investigator |4 oth | |
| 700 | 1 | |a Flick, Lorraine |e investigator |4 oth | |
| 700 | 1 | |a Kingslee, Michelle |e investigator |4 oth | |
| 700 | 1 | |a Smith, Ariana |e investigator |4 oth | |
| 700 | 1 | |a Bonidie, Michael |e investigator |4 oth | |
| 700 | 1 | |a Gruss, Judy |e investigator |4 oth | |
| 700 | 1 | |a Shepherd, Jonathan |e investigator |4 oth | |
| 700 | 1 | |a Sutkin, Gary |e investigator |4 oth | |
| 700 | 1 | |a Zyczynski, Halina M |e investigator |4 oth | |
| 700 | 1 | |a Barber, Matthew |e investigator |4 oth | |
| 700 | 1 | |a Graham, Annette |e investigator |4 oth | |
| 700 | 1 | |a Paraiso, Marie Fidela R |e investigator |4 oth | |
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| 700 | 1 | |a Whitworth, Ryan |e investigator |4 oth | |
| 700 | 1 | |a Swankie, Taylor |e investigator |4 oth | |
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