p63 immunoexpression in hair follicles of normal and alopecia X-affected skin of Pomeranian dogs
© 2023 ESVD and ACVD..
BACKGROUND: Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes.
HYPOTHESIS/OBJECTIVES: The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin.
ANIMALS: Skin biopsies from 19 alopecia X-affected and six control Pomeranians were analysed.
MATERIALS AND METHODS: Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples.
RESULTS: Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles.
CONCLUSIONS AND CLINICAL RELEVANCE: The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Veterinary dermatology - 34(2023), 6 vom: 30. Dez., Seite 567-575 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Della Salda, Leonardo [VerfasserIn] |
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| Links: |
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| Themen: |
Alopecia X |
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| Anmerkungen: |
Date Completed 06.11.2023 Date Revised 06.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/vde.13195 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360188001 |
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| 100 | 1 | |a Della Salda, Leonardo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a p63 immunoexpression in hair follicles of normal and alopecia X-affected skin of Pomeranian dogs |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 06.11.2023 | ||
| 500 | |a Date Revised 06.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 ESVD and ACVD. | ||
| 520 | |a BACKGROUND: Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes | ||
| 520 | |a HYPOTHESIS/OBJECTIVES: The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin | ||
| 520 | |a ANIMALS: Skin biopsies from 19 alopecia X-affected and six control Pomeranians were analysed | ||
| 520 | |a MATERIALS AND METHODS: Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples | ||
| 520 | |a RESULTS: Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles | ||
| 520 | |a CONCLUSIONS AND CLINICAL RELEVANCE: The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a alopecia X | |
| 650 | 4 | |a dog | |
| 650 | 4 | |a follicles | |
| 650 | 4 | |a p63 immunoexpression | |
| 650 | 4 | |a skin development | |
| 650 | 4 | |a transcriptional factor defects | |
| 700 | 1 | |a Bongiovanni, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Massimini, Marcella |e verfasserin |4 aut | |
| 700 | 1 | |a Romanucci, Mariarita |e verfasserin |4 aut | |
| 700 | 1 | |a Vercelli, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Colosimo, Alessia |e verfasserin |4 aut | |
| 700 | 1 | |a Di Matteo, Ramona |e verfasserin |4 aut | |
| 700 | 1 | |a Defourny, Sabrina Vanessa Patrizia |e verfasserin |4 aut | |
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