The administration of methotrexate in patients with Still's disease, "real-life" findings from AIDA Network Still Disease Registry
Copyright © 2023. Published by Elsevier Inc..
OBJECTIVES: To describe clinical characteristics of patients with Still's disease treated with methotrexate (MTX) and to assess drug effectiveness evaluating change in disease activity, reduction of inflammatory markers, and glucocorticoid (GC)-sparing effect.
METHODS: Patients with Still's disease treated with MTX were assessed among those included in AIDA Network Still Disease Registry.
RESULTS: In this registry, 171 patients with Still's disease were treated with MTX (males 43.3%, age 37.1 ± 16.0 years). They were mainly characterised by joint features and fever without a prominent multiorgan involvement. MTX was administered with GCs in 68.4% of patients, with other conventional synthetic DMARDs in 6.4%, and with biologic DMARDs in 25.1%. A significant reduction of the modified systemic score was observed, and 38.6% patients were codified as being in clinical remission at the end of follow-up. The concomitant administration of a biologic DMARD resulted a predictor of the clinical remission. Furthermore, a reduction of inflammatory markers and ferritin levels was observed following the administration of MTX. Additionally, a marked reduction of the dosage of concomitant GCs was identified, while 36.7% discontinued such drugs. Male gender appeared as a predictor of GC discontinuation. MTX was discontinued in 12.3% of patients because of adverse effects, and in 12.3% for lack of efficacy.
CONCLUSIONS: Clinical characteristics of patients with Still's disease treated with MTX were described, mainly joint features and fever without a prominent multiorgan involvement. The clinical usefulness of MTX was reported in reducing the disease activity, decreasing the inflammatory markers, and as GC-sparing agent.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Seminars in arthritis and rheumatism - 62(2023) vom: 07. Okt., Seite 152244 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Adult-onset still's disease |
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| Anmerkungen: |
Date Completed 01.09.2023 Date Revised 06.09.2023 published: Print-Electronic ClinicalTrials.gov: NCT05200715 Citation Status MEDLINE |
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| doi: |
10.1016/j.semarthrit.2023.152244 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 4 | |a The administration of methotrexate in patients with Still's disease, "real-life" findings from AIDA Network Still Disease Registry |
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| 500 | |a ClinicalTrials.gov: NCT05200715 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier Inc. | ||
| 520 | |a OBJECTIVES: To describe clinical characteristics of patients with Still's disease treated with methotrexate (MTX) and to assess drug effectiveness evaluating change in disease activity, reduction of inflammatory markers, and glucocorticoid (GC)-sparing effect | ||
| 520 | |a METHODS: Patients with Still's disease treated with MTX were assessed among those included in AIDA Network Still Disease Registry | ||
| 520 | |a RESULTS: In this registry, 171 patients with Still's disease were treated with MTX (males 43.3%, age 37.1 ± 16.0 years). They were mainly characterised by joint features and fever without a prominent multiorgan involvement. MTX was administered with GCs in 68.4% of patients, with other conventional synthetic DMARDs in 6.4%, and with biologic DMARDs in 25.1%. A significant reduction of the modified systemic score was observed, and 38.6% patients were codified as being in clinical remission at the end of follow-up. The concomitant administration of a biologic DMARD resulted a predictor of the clinical remission. Furthermore, a reduction of inflammatory markers and ferritin levels was observed following the administration of MTX. Additionally, a marked reduction of the dosage of concomitant GCs was identified, while 36.7% discontinued such drugs. Male gender appeared as a predictor of GC discontinuation. MTX was discontinued in 12.3% of patients because of adverse effects, and in 12.3% for lack of efficacy | ||
| 520 | |a CONCLUSIONS: Clinical characteristics of patients with Still's disease treated with MTX were described, mainly joint features and fever without a prominent multiorgan involvement. The clinical usefulness of MTX was reported in reducing the disease activity, decreasing the inflammatory markers, and as GC-sparing agent | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adult-onset still's disease | |
| 650 | 4 | |a Methotrexate | |
| 650 | 4 | |a Still's disease | |
| 650 | 4 | |a Systemic juvenile idiopathic arthritis | |
| 650 | 4 | |a Treatment | |
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| 650 | 7 | |a Glucocorticoids |2 NLM | |
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