Mesenchymal stromal cell-derived magnetic nanovesicles for enhanced skin retention and hair follicle growth
Copyright © 2023 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved..
BACKGROUND AIMS: Extracellular vesicles and exosome-mimetic nanovesicles (NVs) derived from mesenchymal stromal cells (MSCs) have emerged as promising to promote hair growth. However, short local skin retention after subcutaneous administration hinders their clinical applications.
METHODS: In this study, we prepared magnetic nanovesicles (MNVs) from iron oxide nanoparticle-incorporated MSCs. MNVs contained more therapeutic growth factors than NVs derived from naive MSCs, and their localization and internalization were manipulated by external magnetic field.
RESULTS: Following the subcutaneous injection of MNVs into a mouse model of depilation-induced hair regeneration, the magnetic attraction increased their skin retention. Then, the cellular proliferation and β-catenin signaling in hair follicles (HF) were markedly enhanced by MNV injection and magnetic field application. Furthermore, an acceleration of HF growth was revealed by histological analysis.
CONCLUSIONS: The proposed strategy can enhance the therapeutic potential of MSC-derived NVs for hair regeneration and other dermatological diseases.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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Enthalten in: |
Cytotherapy - 25(2023), 11 vom: 12. Nov., Seite 1176-1185 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wang, Lei [VerfasserIn] |
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Links: |
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Themen: |
Extracellular vesicles |
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Anmerkungen: |
Date Completed 30.10.2023 Date Revised 01.11.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.jcyt.2023.07.001 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM360168094 |
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520 | |a Copyright © 2023 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved. | ||
520 | |a BACKGROUND AIMS: Extracellular vesicles and exosome-mimetic nanovesicles (NVs) derived from mesenchymal stromal cells (MSCs) have emerged as promising to promote hair growth. However, short local skin retention after subcutaneous administration hinders their clinical applications | ||
520 | |a METHODS: In this study, we prepared magnetic nanovesicles (MNVs) from iron oxide nanoparticle-incorporated MSCs. MNVs contained more therapeutic growth factors than NVs derived from naive MSCs, and their localization and internalization were manipulated by external magnetic field | ||
520 | |a RESULTS: Following the subcutaneous injection of MNVs into a mouse model of depilation-induced hair regeneration, the magnetic attraction increased their skin retention. Then, the cellular proliferation and β-catenin signaling in hair follicles (HF) were markedly enhanced by MNV injection and magnetic field application. Furthermore, an acceleration of HF growth was revealed by histological analysis | ||
520 | |a CONCLUSIONS: The proposed strategy can enhance the therapeutic potential of MSC-derived NVs for hair regeneration and other dermatological diseases | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a extracellular vesicles | |
650 | 4 | |a hair growth | |
650 | 4 | |a iron oxide nanoparticles | |
650 | 4 | |a mesenchymal stromal cells | |
650 | 4 | |a nanovesicles | |
700 | 1 | |a Qiao, Shuya |e verfasserin |4 aut | |
700 | 1 | |a Xia, Rushan |e verfasserin |4 aut | |
700 | 1 | |a Liu, Yiwen |e verfasserin |4 aut | |
700 | 1 | |a Hu, Yifei |e verfasserin |4 aut | |
700 | 1 | |a Wu, Yajuan |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Junhao |e verfasserin |4 aut | |
700 | 1 | |a Liang, Gaofeng |e verfasserin |4 aut | |
700 | 1 | |a Tian, Tian |e verfasserin |4 aut | |
700 | 1 | |a Cao, Lei |e verfasserin |4 aut | |
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