Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.
METHODS: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.
RESULTS: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).
DISCUSSION: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - (2023) vom: 28. Juli |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rondaan, Christien [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Culture |
|---|
| Anmerkungen: |
Date Revised 19.08.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.cmi.2023.07.018 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM360162509 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM360162509 | ||
| 003 | DE-627 | ||
| 005 | 20231226082426.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cmi.2023.07.018 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1200.xml |
| 035 | |a (DE-627)NLM360162509 | ||
| 035 | |a (NLM)37516385 | ||
| 035 | |a (PII)S1198-743X(23)00345-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rondaan, Christien |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant? |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 19.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC | ||
| 520 | |a METHODS: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study | ||
| 520 | |a RESULTS: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08) | ||
| 520 | |a DISCUSSION: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Culture | |
| 650 | 4 | |a EBJIS | |
| 650 | 4 | |a Periprosthetic joint infection | |
| 650 | 4 | |a Single positive culture | |
| 650 | 4 | |a Sonication | |
| 700 | 1 | |a Maso, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Birlutiu, Rares-Mircea |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez Sampedro, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Soriano, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a Diaz de Brito, Vicens |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez Junyent, Joan |e verfasserin |4 aut | |
| 700 | 1 | |a Del Toro, Maria Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Hofstaetter, Jochen Gerhard |e verfasserin |4 aut | |
| 700 | 1 | |a Salles, Mauro José |e verfasserin |4 aut | |
| 700 | 1 | |a Esteban, Jaime |e verfasserin |4 aut | |
| 700 | 1 | |a Wouthuyzen-Bakker, Marjan |e verfasserin |4 aut | |
| 700 | 0 | |a ESCMID Study Group on Implant Associated Infections (ESGIAI) |e verfasserin |4 aut | |
| 700 | 1 | |a Frank, Bernhard J H |e investigator |4 oth | |
| 700 | 1 | |a Auñon, Alvaro |e investigator |4 oth | |
| 700 | 1 | |a Morata, Laura |e investigator |4 oth | |
| 700 | 1 | |a Birlutiu, Victoria |e investigator |4 oth | |
| 700 | 1 | |a Storni, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Sorli, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Horcajada, Juan Pablo |e investigator |4 oth | |
| 700 | 1 | |a Hamburger, Flávio Guinsburg |e investigator |4 oth | |
| 700 | 1 | |a Salas Venero, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Pietro, Cimatti |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |d 1995 |g (2023) vom: 28. Juli |w (DE-627)NLM094580014 |x 1469-0691 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:28 |g month:07 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.cmi.2023.07.018 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 28 |c 07 | ||