Associations between neuromyelitis optica spectrum disorder, Sjögren's syndrome, and conditions with electrolyte disturbances
Copyright © 2023 Elsevier B.V. All rights reserved..
OBJECTIVE: Electrolyte disorders are among the important conditions negatively affecting the disease course of neuromyelitis optica spectrum disorder (NMOSD). Possible mechanisms may include renal tubular acidosis (RTA) accompanying Sjögren's syndrome (SS), syndrome of inappropriate antidiuretic hormone secretion (SIADH), and central diabetes insipidus (DI). Currently, the overlap profiles between these conditions remain uncertain.
METHODS: This cross-sectional study collected data from the nationwide administrative Diagnosis Procedure Combination (DPC) database and evaluated the overlap profiles.
RESULTS: Among the 28,285,908 individuals from 1203 DPC-covered hospitals, 8477 had NMOSD, 174108 had SS, 4977 had RTA, 7640 had SIADH, and 24,789 had central DI. Of those with NMOSD, 986 (12%) had SS. The odds ratio (OR) for a diagnosis of NMOSD in those with SS compared with those without was 21 [95% confidence interval (CI), 20-23]. Overlap between NMOSD and SS was seen both in males (OR, 28 [95% CI, 23-33]) and females (OR, 16 [15-17]) and was more prominent in the younger population. Among patients with SS, the prevalence of RTA was lower in patients with NMOSD compared with those without NMOSD. Patients with NMOSD showed a higher prevalence of SIADH (OR, 11 [7.5-17]; p < 0.0001) and DI (OR, 3.7 [2.4-5.3]; p < 0.0001). Comorbid SS in NMOSD was associated with a higher prevalence of DI.
CONCLUSIONS: Patients with NMOSD are likely to have SS, SIADH, and central DI. RTA in SS does not facilitate the overlap between NMOSD and SS. SS in NMOSD may predispose patients to DI.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:452 |
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| Enthalten in: |
Journal of the neurological sciences - 452(2023) vom: 15. Sept., Seite 120742 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Akaishi, Tetsuya [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.09.2023 Date Revised 13.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jns.2023.120742 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360157149 |
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| 100 | 1 | |a Akaishi, Tetsuya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Associations between neuromyelitis optica spectrum disorder, Sjögren's syndrome, and conditions with electrolyte disturbances |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 13.09.2023 | ||
| 500 | |a Date Revised 13.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: Electrolyte disorders are among the important conditions negatively affecting the disease course of neuromyelitis optica spectrum disorder (NMOSD). Possible mechanisms may include renal tubular acidosis (RTA) accompanying Sjögren's syndrome (SS), syndrome of inappropriate antidiuretic hormone secretion (SIADH), and central diabetes insipidus (DI). Currently, the overlap profiles between these conditions remain uncertain | ||
| 520 | |a METHODS: This cross-sectional study collected data from the nationwide administrative Diagnosis Procedure Combination (DPC) database and evaluated the overlap profiles | ||
| 520 | |a RESULTS: Among the 28,285,908 individuals from 1203 DPC-covered hospitals, 8477 had NMOSD, 174108 had SS, 4977 had RTA, 7640 had SIADH, and 24,789 had central DI. Of those with NMOSD, 986 (12%) had SS. The odds ratio (OR) for a diagnosis of NMOSD in those with SS compared with those without was 21 [95% confidence interval (CI), 20-23]. Overlap between NMOSD and SS was seen both in males (OR, 28 [95% CI, 23-33]) and females (OR, 16 [15-17]) and was more prominent in the younger population. Among patients with SS, the prevalence of RTA was lower in patients with NMOSD compared with those without NMOSD. Patients with NMOSD showed a higher prevalence of SIADH (OR, 11 [7.5-17]; p < 0.0001) and DI (OR, 3.7 [2.4-5.3]; p < 0.0001). Comorbid SS in NMOSD was associated with a higher prevalence of DI | ||
| 520 | |a CONCLUSIONS: Patients with NMOSD are likely to have SS, SIADH, and central DI. RTA in SS does not facilitate the overlap between NMOSD and SS. SS in NMOSD may predispose patients to DI | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Neuromyelitis optica spectrum disorder (NMOSD) | |
| 650 | 4 | |a Overlap | |
| 650 | 4 | |a Renal tubular acidosis | |
| 650 | 4 | |a Sjögren's syndrome | |
| 650 | 4 | |a Syndrome of inappropriate antidiuretic hormone secretion (SIADH) | |
| 650 | 7 | |a Electrolytes |2 NLM | |
| 650 | 7 | |a Aquaporin 4 |2 NLM | |
| 700 | 1 | |a Tarasawa, Kunio |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Sandhya, Pulukool |e verfasserin |4 aut | |
| 700 | 1 | |a Misu, Tatsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Fushimi, Kiyohide |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Toshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimori, Juichi |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimori, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Yaegashi, Nobuo |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Ichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Fujihara, Kazuo |e verfasserin |4 aut | |
| 700 | 1 | |a Aoki, Masashi |e verfasserin |4 aut | |
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