Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV
Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 2006-2021 in two international cohort collaborations (D:A:D and RESPOND). Poisson regression was used to assess temporal trends, adjusted for potential confounders. Amongst 64,937 individuals (31% ART-naïve at baseline) and 490,376 total person-years of follow-up (PYFU), there were 3763 incident cancers (IR 7.7/1000 PYFU [95% CI 7.4, 7.9]): 950 AIDS-defining cancers (ADCs), 2813 non-ADCs, 1677 infection-related cancers, 1372 smoking-related cancers, and 719 BMI-related cancers (groups were not mutually exclusive). Age-standardised IRs for overall cancer remained fairly constant over time (8.22/1000 PYFU [7.52, 8.97] in 2006-2007, 7.54 [6.59, 8.59] in 2020-2021). The incidence of ADCs (3.23 [2.79, 3.72], 0.99 [0.67, 1.42]) and infection-related cancers (4.83 [4.2, 5.41], 2.43 [1.90, 3.05]) decreased over time, whilst the incidence of non-ADCs (4.99 [4.44, 5.58], 6.55 [5.67, 7.53]), smoking-related cancers (2.38 [2.01, 2.79], 3.25 [2.63-3.96]), and BMI-related cancers (1.07 [0.83, 1.37], 1.88 [1.42, 2.44]) increased. Trends were similar after adjusting for demographics, comorbidities, HIV-related factors, and ART use. These results highlight the need for better prevention strategies to reduce the incidence of NADCs, smoking-, and BMI-related cancers.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
---|---|
Enthalten in: |
Cancers - 15(2023), 14 vom: 15. Juli |
Sprache: |
Englisch |
---|
Links: |
---|
Themen: |
AIDS defining cancer |
---|
Anmerkungen: |
Date Revised 31.07.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3390/cancers15143640 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM360091717 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM360091717 | ||
003 | DE-627 | ||
005 | 20231226082256.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/cancers15143640 |2 doi | |
028 | 5 | 2 | |a pubmed24n1200.xml |
035 | |a (DE-627)NLM360091717 | ||
035 | |a (NLM)37509301 | ||
035 | |a (PII)3640 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Greenberg, Lauren |e verfasserin |4 aut | |
245 | 1 | 0 | |a Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 31.07.2023 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 2006-2021 in two international cohort collaborations (D:A:D and RESPOND). Poisson regression was used to assess temporal trends, adjusted for potential confounders. Amongst 64,937 individuals (31% ART-naïve at baseline) and 490,376 total person-years of follow-up (PYFU), there were 3763 incident cancers (IR 7.7/1000 PYFU [95% CI 7.4, 7.9]): 950 AIDS-defining cancers (ADCs), 2813 non-ADCs, 1677 infection-related cancers, 1372 smoking-related cancers, and 719 BMI-related cancers (groups were not mutually exclusive). Age-standardised IRs for overall cancer remained fairly constant over time (8.22/1000 PYFU [7.52, 8.97] in 2006-2007, 7.54 [6.59, 8.59] in 2020-2021). The incidence of ADCs (3.23 [2.79, 3.72], 0.99 [0.67, 1.42]) and infection-related cancers (4.83 [4.2, 5.41], 2.43 [1.90, 3.05]) decreased over time, whilst the incidence of non-ADCs (4.99 [4.44, 5.58], 6.55 [5.67, 7.53]), smoking-related cancers (2.38 [2.01, 2.79], 3.25 [2.63-3.96]), and BMI-related cancers (1.07 [0.83, 1.37], 1.88 [1.42, 2.44]) increased. Trends were similar after adjusting for demographics, comorbidities, HIV-related factors, and ART use. These results highlight the need for better prevention strategies to reduce the incidence of NADCs, smoking-, and BMI-related cancers | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a AIDS defining cancer | |
650 | 4 | |a HIV | |
650 | 4 | |a body mass index | |
650 | 4 | |a incidence | |
650 | 4 | |a infection | |
650 | 4 | |a non-AIDS defining cancer | |
650 | 4 | |a smoking | |
650 | 4 | |a trends | |
700 | 1 | |a Ryom, Lene |e verfasserin |4 aut | |
700 | 1 | |a Bakowska, Elzbieta |e verfasserin |4 aut | |
700 | 1 | |a Wit, Ferdinand |e verfasserin |4 aut | |
700 | 1 | |a Bucher, Heiner C |e verfasserin |4 aut | |
700 | 1 | |a Braun, Dominique L |e verfasserin |4 aut | |
700 | 1 | |a Phillips, Andrew |e verfasserin |4 aut | |
700 | 1 | |a Sabin, Caroline |e verfasserin |4 aut | |
700 | 1 | |a d'Arminio Monforte, Antonella |e verfasserin |4 aut | |
700 | 1 | |a Zangerle, Robert |e verfasserin |4 aut | |
700 | 1 | |a Smith, Colette |e verfasserin |4 aut | |
700 | 1 | |a De Wit, Stéphane |e verfasserin |4 aut | |
700 | 1 | |a Bonnet, Fabrice |e verfasserin |4 aut | |
700 | 1 | |a Pradier, Christian |e verfasserin |4 aut | |
700 | 1 | |a Mussini, Cristina |e verfasserin |4 aut | |
700 | 1 | |a Muccini, Camilla |e verfasserin |4 aut | |
700 | 1 | |a Vehreschild, Jörg J |e verfasserin |4 aut | |
700 | 1 | |a Hoy, Jennifer |e verfasserin |4 aut | |
700 | 1 | |a Svedhem, Veronica |e verfasserin |4 aut | |
700 | 1 | |a Miró, Jose M |e verfasserin |4 aut | |
700 | 1 | |a Wasmuth, Jan-Christian |e verfasserin |4 aut | |
700 | 1 | |a Reiss, Peter |e verfasserin |4 aut | |
700 | 1 | |a Llibre, Josep M |e verfasserin |4 aut | |
700 | 1 | |a Chkhartishvili, Nikoloz |e verfasserin |4 aut | |
700 | 1 | |a Stephan, Christoph |e verfasserin |4 aut | |
700 | 1 | |a Hatleberg, Camilla I |e verfasserin |4 aut | |
700 | 1 | |a Neesgaard, Bastian |e verfasserin |4 aut | |
700 | 1 | |a Peters, Lars |e verfasserin |4 aut | |
700 | 1 | |a Jaschinski, Nadine |e verfasserin |4 aut | |
700 | 1 | |a Dedes, Nikos |e verfasserin |4 aut | |
700 | 1 | |a Kuzovatova, Elena |e verfasserin |4 aut | |
700 | 1 | |a Van Der Valk, Marc |e verfasserin |4 aut | |
700 | 1 | |a Menozzi, Marianna |e verfasserin |4 aut | |
700 | 1 | |a Lehmann, Clara |e verfasserin |4 aut | |
700 | 1 | |a Petoumenos, Kathy |e verfasserin |4 aut | |
700 | 1 | |a Garges, Harmony |e verfasserin |4 aut | |
700 | 1 | |a Rooney, Jim |e verfasserin |4 aut | |
700 | 1 | |a Young, Lital |e verfasserin |4 aut | |
700 | 1 | |a Lundgren, Jens D |e verfasserin |4 aut | |
700 | 1 | |a Bansi-Matharu, Loveleen |e verfasserin |4 aut | |
700 | 1 | |a Mocroft, Amanda |e verfasserin |4 aut | |
700 | 1 | |a On Behalf Of The Respond And D A D Study Groups |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Cancers |d 2009 |g 15(2023), 14 vom: 15. Juli |w (DE-627)NLM198667213 |x 2072-6694 |7 nnns |
773 | 1 | 8 | |g volume:15 |g year:2023 |g number:14 |g day:15 |g month:07 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/cancers15143640 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 15 |j 2023 |e 14 |b 15 |c 07 |