A self-unfolding proximity enabling device for oral delivery of macromolecules
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved..
Oral delivery of macromolecules remains highly challenging due to their rapid degradation in the gastrointestinal tract and poor absorption across the tight junctions of the epithelium. In the last decade, researchers have investigated several medical devices to overcome these challenges using various approaches, some of which involve piercing through the intestine using micro and macro needles. We have developed a new generation of medical devices called self-unfolding proximity enabling devices, which makes it possible to orally deliver macromolecules without perforating the intestine. These devices protect macromolecules from the harsh conditions in the stomach and release their active pharmaceutical ingredients in the vicinity of the intestinal epithelium. One device version is a self-unfolding foil that we have used to deliver insulin and nisin to rats and pigs respectively. In our study, this device has shown a great potential for delivering peptides, with a significant increase in the absorption of solid dosage of insulin by ∼12 times and nisin by ∼4 times in rats and pigs, respectively. With the ability to load solid dosage forms, our devices can facilitate enhanced absorption of minimally invasive oral macromolecule formulations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:361 |
|---|---|
| Enthalten in: |
Journal of controlled release : official journal of the Controlled Release Society - 361(2023) vom: 26. Sept., Seite 40-52 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ghavami, Mahdi [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 11.09.2023 Date Revised 18.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jconrel.2023.07.041 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM360067271 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM360067271 | ||
| 003 | DE-627 | ||
| 005 | 20231226082224.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jconrel.2023.07.041 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1200.xml |
| 035 | |a (DE-627)NLM360067271 | ||
| 035 | |a (NLM)37506850 | ||
| 035 | |a (PII)S0168-3659(23)00465-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ghavami, Mahdi |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A self-unfolding proximity enabling device for oral delivery of macromolecules |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.09.2023 | ||
| 500 | |a Date Revised 18.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Oral delivery of macromolecules remains highly challenging due to their rapid degradation in the gastrointestinal tract and poor absorption across the tight junctions of the epithelium. In the last decade, researchers have investigated several medical devices to overcome these challenges using various approaches, some of which involve piercing through the intestine using micro and macro needles. We have developed a new generation of medical devices called self-unfolding proximity enabling devices, which makes it possible to orally deliver macromolecules without perforating the intestine. These devices protect macromolecules from the harsh conditions in the stomach and release their active pharmaceutical ingredients in the vicinity of the intestinal epithelium. One device version is a self-unfolding foil that we have used to deliver insulin and nisin to rats and pigs respectively. In our study, this device has shown a great potential for delivering peptides, with a significant increase in the absorption of solid dosage of insulin by ∼12 times and nisin by ∼4 times in rats and pigs, respectively. With the ability to load solid dosage forms, our devices can facilitate enhanced absorption of minimally invasive oral macromolecule formulations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Drug delivery device | |
| 650 | 4 | |a Elastomer | |
| 650 | 4 | |a Ingestible device | |
| 650 | 4 | |a Oral delivery of macromolecule | |
| 650 | 4 | |a Oral insulin | |
| 650 | 4 | |a Polydimethylsiloxane (PDMS) | |
| 650 | 7 | |a Nisin |2 NLM | |
| 650 | 7 | |a 1414-45-5 |2 NLM | |
| 650 | 7 | |a Pharmaceutical Preparations |2 NLM | |
| 650 | 7 | |a Macromolecular Substances |2 NLM | |
| 650 | 7 | |a Insulin |2 NLM | |
| 700 | 1 | |a Pedersen, Jesper |e verfasserin |4 aut | |
| 700 | 1 | |a Kjeldsen, Rolf Bech |e verfasserin |4 aut | |
| 700 | 1 | |a Alstrup, Aage Kristian Olsen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhongyang |e verfasserin |4 aut | |
| 700 | 1 | |a Koulianou, Vasiliki |e verfasserin |4 aut | |
| 700 | 1 | |a Palmfeldt, Johan |e verfasserin |4 aut | |
| 700 | 1 | |a Vorup-Jensen, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Thamdrup, Lasse Højlund Eklund |e verfasserin |4 aut | |
| 700 | 1 | |a Boisen, Anja |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of controlled release : official journal of the Controlled Release Society |d 1996 |g 361(2023) vom: 26. Sept., Seite 40-52 |w (DE-627)NLM085820296 |x 1873-4995 |7 nnns |
| 773 | 1 | 8 | |g volume:361 |g year:2023 |g day:26 |g month:09 |g pages:40-52 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jconrel.2023.07.041 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 361 |j 2023 |b 26 |c 09 |h 40-52 | ||