Polysaccharide-Based Hydrogel from Seeds of Artemisia vulgaris : Extraction Optimization by Box-Behnken Design, pH-Responsiveness, and Sustained Drug Release
The current research work focuses on the extraction and optimization of the hydrogel (AVM) from the seeds of Artemisia vulgaris using Box-Behnken design-response surface methodology (BBD-RSM). The AVM was obtained through a hot water extraction process. The influence of different factors, including pH (U = 4 to 10), temperature (V = 25 to 110 °C), seed/water ratio, i.e., S/W ratio (W = 1/10 to 1/70 w/v), and seed/water contact time, i.e., S/W time (X = 1 to 12 h) on the yield of AVM was evaluated. The p-value for the analysis of variance (ANOVA) was found to be <0.001, indicating that the yield of AVM mainly depended on the abovementioned factors. The highest yield of AVM, i.e., 15.86%, was found at a pH of 7.12, temperature of 80.04 °C, S/W ratio of 1/33.24 w/v, and S/W time of 8.73 h according to Design-Expert Software. The study of the pH-responsive behavior of AVM in tablet form (formulation AVT3) revealed that AVM is a pH-responsive material with significantly high swelling at pH 7.4. However, less swelling was witnessed at pH 1.2. Moreover, AVM was found to be a sustained release material for esomeprazole at pH 7.4 for 12 h. The drug release from AVT3 was according to the super case-II transport mechanism and zero-order kinetics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Gels (Basel, Switzerland) - 9(2023), 7 vom: 28. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hussain, Muhammad Ajaz [VerfasserIn] |
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| Links: |
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| Themen: |
Artemisia vulgaris hydrogel |
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| Anmerkungen: |
Date Revised 01.08.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/gels9070525 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360043127 |
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| 100 | 1 | |a Hussain, Muhammad Ajaz |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Polysaccharide-Based Hydrogel from Seeds of Artemisia vulgaris |b Extraction Optimization by Box-Behnken Design, pH-Responsiveness, and Sustained Drug Release |
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| 500 | |a Date Revised 01.08.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a The current research work focuses on the extraction and optimization of the hydrogel (AVM) from the seeds of Artemisia vulgaris using Box-Behnken design-response surface methodology (BBD-RSM). The AVM was obtained through a hot water extraction process. The influence of different factors, including pH (U = 4 to 10), temperature (V = 25 to 110 °C), seed/water ratio, i.e., S/W ratio (W = 1/10 to 1/70 w/v), and seed/water contact time, i.e., S/W time (X = 1 to 12 h) on the yield of AVM was evaluated. The p-value for the analysis of variance (ANOVA) was found to be <0.001, indicating that the yield of AVM mainly depended on the abovementioned factors. The highest yield of AVM, i.e., 15.86%, was found at a pH of 7.12, temperature of 80.04 °C, S/W ratio of 1/33.24 w/v, and S/W time of 8.73 h according to Design-Expert Software. The study of the pH-responsive behavior of AVM in tablet form (formulation AVT3) revealed that AVM is a pH-responsive material with significantly high swelling at pH 7.4. However, less swelling was witnessed at pH 1.2. Moreover, AVM was found to be a sustained release material for esomeprazole at pH 7.4 for 12 h. The drug release from AVT3 was according to the super case-II transport mechanism and zero-order kinetics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Artemisia vulgaris hydrogel | |
| 650 | 4 | |a Box–Behnken design | |
| 650 | 4 | |a pH-responsiveness | |
| 650 | 4 | |a response surface methodology | |
| 650 | 4 | |a sustained release | |
| 700 | 1 | |a Ali, Arshad |e verfasserin |4 aut | |
| 700 | 1 | |a Alsahli, Tariq G |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Nadia |e verfasserin |4 aut | |
| 700 | 1 | |a Sharif, Ahsan |e verfasserin |4 aut | |
| 700 | 1 | |a Haseeb, Muhammad Tahir |e verfasserin |4 aut | |
| 700 | 1 | |a Alsaidan, Omar Awad |e verfasserin |4 aut | |
| 700 | 1 | |a Tayyab, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Bukhari, Syed Nasir Abbas |e verfasserin |4 aut | |
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