Molecular Role of Asn680Ser and Asp37Glu Missense Variants in Saudi Women with Female Infertility and Polycystic Ovarian Syndrome
Female infertility (FI) is a global health issue. Polycystic ovary syndrome (PCOS) is a common cause of FI. The renalase gene (RNLS) is associated with FI and other human diseases. Based on the documented missense variants, rs6166 and rs2296545 single-nucleotide polymorphisms (SNPs) were not identified in Saudi women with FI and PCOS. This study aimed to investigate the molecular role of the two SNPs in Saudi women with FI and PCOS. In this cross-sectional study, 96 healthy controls, 96 women with FI, and 96 women with PCOS were recruited. DNA was isolated, and polymerase chain reactions and Sanger sequencing analysis were performed using rs6166 and rs2296545 SNPs. The data obtained from the three groups were used to perform statistical analyses based on genotype, allele frequencies, regression models, and ANOVA analysis. Both rs6166 and rs2296545 had no role in FI or PCOS in Saudi women. A predicted reason for non-association in Saudi women could be the role of elderly women in the controls compared with women with FI and PCOS. Moreover, age, weight, and body mass index were higher in the control group than the FI and PCOS groups. In conclusion, rs6166 and rs2296545 SNPs were not associated with FI or PCOS in Saudi women.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Current issues in molecular biology - 45(2023), 7 vom: 29. Juni, Seite 5494-5514 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alshammary, Amal F [VerfasserIn] |
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| Links: |
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| Themen: |
FSHR |
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| Anmerkungen: |
Date Revised 31.07.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/cimb45070348 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360041736 |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Female infertility (FI) is a global health issue. Polycystic ovary syndrome (PCOS) is a common cause of FI. The renalase gene (RNLS) is associated with FI and other human diseases. Based on the documented missense variants, rs6166 and rs2296545 single-nucleotide polymorphisms (SNPs) were not identified in Saudi women with FI and PCOS. This study aimed to investigate the molecular role of the two SNPs in Saudi women with FI and PCOS. In this cross-sectional study, 96 healthy controls, 96 women with FI, and 96 women with PCOS were recruited. DNA was isolated, and polymerase chain reactions and Sanger sequencing analysis were performed using rs6166 and rs2296545 SNPs. The data obtained from the three groups were used to perform statistical analyses based on genotype, allele frequencies, regression models, and ANOVA analysis. Both rs6166 and rs2296545 had no role in FI or PCOS in Saudi women. A predicted reason for non-association in Saudi women could be the role of elderly women in the controls compared with women with FI and PCOS. Moreover, age, weight, and body mass index were higher in the control group than the FI and PCOS groups. In conclusion, rs6166 and rs2296545 SNPs were not associated with FI or PCOS in Saudi women | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a RNLS | |
| 650 | 4 | |a Saudi women | |
| 650 | 4 | |a female infertility | |
| 650 | 4 | |a missense variants | |
| 650 | 4 | |a polycystic ovary syndrome (PCOS) | |
| 650 | 4 | |a rs2296545 | |
| 650 | 4 | |a rs6166 | |
| 700 | 1 | |a Alsobaie, Sarah F |e verfasserin |4 aut | |
| 700 | 1 | |a Alageel, Arwa A |e verfasserin |4 aut | |
| 700 | 1 | |a Aldakheel, Fahad M |e verfasserin |4 aut | |
| 700 | 1 | |a Ansar, Sabah |e verfasserin |4 aut | |
| 700 | 1 | |a Alrashoudi, Reem |e verfasserin |4 aut | |
| 700 | 1 | |a Farzan, Raed |e verfasserin |4 aut | |
| 700 | 1 | |a Alturki, Norah A |e verfasserin |4 aut | |
| 700 | 1 | |a Alhaizan, Maysoon Abdulhadi |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Mutawa, Johara |e verfasserin |4 aut | |
| 700 | 1 | |a Ali Khan, Imran |e verfasserin |4 aut | |
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