Unsupervised home spirometry is not equivalent to supervised clinic spirometry in children and young people with cystic fibrosis : Results from the CLIMB-CF study
© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC..
BACKGROUND: Handheld spirometry allows monitoring of lung function at home, of particular importance during the COVID-19 pandemic. Pediatric studies are unclear on whether values are interchangeable with traditional, clinic-based spirometry. We aimed to assess differences between contemporaneous, home (unsupervised) and clinic (supervised) spirometry and the variability of the former. The accuracy of the commercially available spirometer used in the study was also tested.
METHODS: Data from participants in the Clinical Monitoring and Biomarkers to stratify severity and predict outcomes in children with cystic fibrosisc (CLIMB-CF) Study aged ≥ 6 years who had paired (±1 day) clinic and home forced expiratory volume in 1 s (FEV1 ) readings were analyzed. Variability during clinical stability over 6-months was assessed. Four devices from Vitalograph were tested using 1 and 3 L calibration syringes.
RESULTS: Sixty-seven participants (median [interquartile range] age 10.7 [7.6-13.9] years) provided home and clinic FEV1 data pairs. The mean (SD) FEV1 % bias was 6.5% [±8.2%]) with wide limits of agreement (-9.6% to +22.7%); 76.2% of participants recorded lower results at home. Coefficient of variation of home FEV1 % during stable periods was 9.9%. Data from the testing of the handheld device used in CLIMB-CF showed a potential underread.
CONCLUSION: In children and adolescents, home spirometry using hand-held equipment cannot be used interchangeably with clinic spirometry. Home spirometry is moderately variable during clinical stability. New handheld devices underread, particularly at lower volumes of potential clinical significance for smaller patients; this suggests that supervision does not account fully for the discrepancy. Opportunities should be taken to obtain dual device measurements in clinic, so that trend data from home can be utilized more accurately.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Pediatric pulmonology - 58(2023), 10 vom: 27. Okt., Seite 2871-2880 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Edmondson, Claire [VerfasserIn] |
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| Links: |
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| Themen: |
Cystic fibrosis |
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| Anmerkungen: |
Date Completed 28.09.2023 Date Revised 28.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ppul.26602 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Edmondson, Claire |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Unsupervised home spirometry is not equivalent to supervised clinic spirometry in children and young people with cystic fibrosis |b Results from the CLIMB-CF study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 28.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: Handheld spirometry allows monitoring of lung function at home, of particular importance during the COVID-19 pandemic. Pediatric studies are unclear on whether values are interchangeable with traditional, clinic-based spirometry. We aimed to assess differences between contemporaneous, home (unsupervised) and clinic (supervised) spirometry and the variability of the former. The accuracy of the commercially available spirometer used in the study was also tested | ||
| 520 | |a METHODS: Data from participants in the Clinical Monitoring and Biomarkers to stratify severity and predict outcomes in children with cystic fibrosisc (CLIMB-CF) Study aged ≥ 6 years who had paired (±1 day) clinic and home forced expiratory volume in 1 s (FEV1 ) readings were analyzed. Variability during clinical stability over 6-months was assessed. Four devices from Vitalograph were tested using 1 and 3 L calibration syringes | ||
| 520 | |a RESULTS: Sixty-seven participants (median [interquartile range] age 10.7 [7.6-13.9] years) provided home and clinic FEV1 data pairs. The mean (SD) FEV1 % bias was 6.5% [±8.2%]) with wide limits of agreement (-9.6% to +22.7%); 76.2% of participants recorded lower results at home. Coefficient of variation of home FEV1 % during stable periods was 9.9%. Data from the testing of the handheld device used in CLIMB-CF showed a potential underread | ||
| 520 | |a CONCLUSION: In children and adolescents, home spirometry using hand-held equipment cannot be used interchangeably with clinic spirometry. Home spirometry is moderately variable during clinical stability. New handheld devices underread, particularly at lower volumes of potential clinical significance for smaller patients; this suggests that supervision does not account fully for the discrepancy. Opportunities should be taken to obtain dual device measurements in clinic, so that trend data from home can be utilized more accurately | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cystic fibrosis | |
| 650 | 4 | |a remote monitoring | |
| 650 | 4 | |a remote spirometry | |
| 650 | 4 | |a unsupervised spirometry | |
| 700 | 1 | |a Westrupp, Nicole |e verfasserin |4 aut | |
| 700 | 1 | |a Short, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Seddon, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Olden, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Wallis, Colin |e verfasserin |4 aut | |
| 700 | 1 | |a Brodlie, Malcolm |e verfasserin |4 aut | |
| 700 | 1 | |a Baxter, Francis |e verfasserin |4 aut | |
| 700 | 1 | |a McCormick, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a MacFarlane, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Brooker, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Connon, Margaret |e verfasserin |4 aut | |
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| 700 | 1 | |a Blaikie, Lesley |e verfasserin |4 aut | |
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