Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment
© 2023. The Author(s)..
This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring 1 year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate=39.3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between March-2021 and January-2022. Disorder prevalence was compared against a random non-infected household sample (n=1834). 248 surveys were received on average 321 days post-infection (Mean age: 48.9, 54% female, moderate/severe/critical infection: 58.2%). 32.4% were screened to have at least one mental disorder, 78.7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19.1%) was significantly more common than control (14%, p=0.047). Latent profile analysis classified individuals into P1 (12·4%)-no current neuropsychiatric morbidities, P2 (23.1%)-SCI/fatigue, P3 (45.2%)-anxiety/PTSD, P4 (19.3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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Enthalten in: |
Scientific reports - 13(2023), 1 vom: 27. Juli, Seite 12205 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Leung, Owen N W [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 31.07.2023 Date Revised 01.08.2023 published: Electronic Citation Status MEDLINE |
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doi: |
10.1038/s41598-023-39209-z |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM360006698 |
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520 | |a This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring 1 year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate=39.3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between March-2021 and January-2022. Disorder prevalence was compared against a random non-infected household sample (n=1834). 248 surveys were received on average 321 days post-infection (Mean age: 48.9, 54% female, moderate/severe/critical infection: 58.2%). 32.4% were screened to have at least one mental disorder, 78.7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19.1%) was significantly more common than control (14%, p=0.047). Latent profile analysis classified individuals into P1 (12·4%)-no current neuropsychiatric morbidities, P2 (23.1%)-SCI/fatigue, P3 (45.2%)-anxiety/PTSD, P4 (19.3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors | ||
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700 | 1 | |a Alonso, Jordi |e verfasserin |4 aut | |
700 | 1 | |a Chan, Paul K S |e verfasserin |4 aut | |
700 | 1 | |a Lui, Grace |e verfasserin |4 aut | |
700 | 1 | |a Wong, Eliza |e verfasserin |4 aut | |
700 | 1 | |a Bruffaerts, Ronny |e verfasserin |4 aut | |
700 | 1 | |a Yip, Benjamin H K |e verfasserin |4 aut | |
700 | 1 | |a Mortier, Philippe |e verfasserin |4 aut | |
700 | 1 | |a Vilagut, Gemma |e verfasserin |4 aut | |
700 | 1 | |a Kwok, Dora |e verfasserin |4 aut | |
700 | 1 | |a Lam, Linda C W |e verfasserin |4 aut | |
700 | 1 | |a Kessler, Ronald C |e verfasserin |4 aut | |
700 | 1 | |a Mak, Arthur D P |e verfasserin |4 aut | |
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