Characteristics and management of patients with SARS-CoV2 infection admitted to pediatric intensive care units : Data analysis of the Spanish national multicenter registry
© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC..
INTRODUCTION: The purpose of this study is to describe the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) disease characteristics and management in children admitted to the pediatric intensive care units (PICU).
METHODS: The present study was based on a national multicentric prospective registry including PICU patients with SARS-CoV2 infection or symptoms of multisystem inflammatory syndrome in children (MIS-C).
RESULTS: A total of 298 patients were admitted to 41 different Spanish PICUs. A total of 76% of them were previously healthy. The most frequent manifestation was MIS-C (69.8%). On admission, 59.4% of patients did not have respiratory distress, and only 17.4% needed conventional mechanical ventilation (MV). The need for MV was associated with age (incidence rate ratios [IRR] 1.21, p < .012), pediatric sequential organ failure assessment score (p-SOFA) Score (IRR 1.12, p = .001), and need for transfusion (IRR 4.5, p < .004) in MIS-C patients, and with vasoactive drug use (IRR 2.73, p = .022) and the diagnosis of acute respiratory distress syndrome (IRR 2.83, p = .018) in patients admitted for other reasons. During the first day of admission, 56% of patients met shock criteria and 50.7% needed vasoactive drugs. In MIS-C patients, their use was associated with higher p-SOFA score (IRR 1.06, p < .001) and with the diagnosis of shock (IRR 5.78, p < .001). In patients without MIS-C, it was associated with higher p-SOFA score (IRR 1.05, p = .022). The mortality rate was 3%, being lower in MIS-C patients compared to patients admitted for other reasons (0.5% vs. 9.4%, p < .001). It was also lower in previously healthy patients compared to patients with previous comorbidities (0.9% vs. 9.7%, p < .001).
CONCLUSIONS: Severe SARS-CoV2 infection is uncommon in the pediatric population. In our series, respiratory distress was rare, being MIS-C the most frequent cause of PICU admission related to SARS-CoV2. In most cases, the course of the disease was mild except in children with previous diseases.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
|---|---|
| Enthalten in: |
Pediatric pulmonology - 58(2023), 10 vom: 28. Okt., Seite 2916-2929 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Slöcker Barrio, María [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
ARDS |
|---|
| Anmerkungen: |
Date Completed 28.09.2023 Date Revised 28.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/ppul.26613 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM359932991 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM359932991 | ||
| 003 | DE-627 | ||
| 005 | 20231226081929.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ppul.26613 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1199.xml |
| 035 | |a (DE-627)NLM359932991 | ||
| 035 | |a (NLM)37493137 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Slöcker Barrio, María |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characteristics and management of patients with SARS-CoV2 infection admitted to pediatric intensive care units |b Data analysis of the Spanish national multicenter registry |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.09.2023 | ||
| 500 | |a Date Revised 28.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC. | ||
| 520 | |a INTRODUCTION: The purpose of this study is to describe the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) disease characteristics and management in children admitted to the pediatric intensive care units (PICU) | ||
| 520 | |a METHODS: The present study was based on a national multicentric prospective registry including PICU patients with SARS-CoV2 infection or symptoms of multisystem inflammatory syndrome in children (MIS-C) | ||
| 520 | |a RESULTS: A total of 298 patients were admitted to 41 different Spanish PICUs. A total of 76% of them were previously healthy. The most frequent manifestation was MIS-C (69.8%). On admission, 59.4% of patients did not have respiratory distress, and only 17.4% needed conventional mechanical ventilation (MV). The need for MV was associated with age (incidence rate ratios [IRR] 1.21, p < .012), pediatric sequential organ failure assessment score (p-SOFA) Score (IRR 1.12, p = .001), and need for transfusion (IRR 4.5, p < .004) in MIS-C patients, and with vasoactive drug use (IRR 2.73, p = .022) and the diagnosis of acute respiratory distress syndrome (IRR 2.83, p = .018) in patients admitted for other reasons. During the first day of admission, 56% of patients met shock criteria and 50.7% needed vasoactive drugs. In MIS-C patients, their use was associated with higher p-SOFA score (IRR 1.06, p < .001) and with the diagnosis of shock (IRR 5.78, p < .001). In patients without MIS-C, it was associated with higher p-SOFA score (IRR 1.05, p = .022). The mortality rate was 3%, being lower in MIS-C patients compared to patients admitted for other reasons (0.5% vs. 9.4%, p < .001). It was also lower in previously healthy patients compared to patients with previous comorbidities (0.9% vs. 9.7%, p < .001) | ||
| 520 | |a CONCLUSIONS: Severe SARS-CoV2 infection is uncommon in the pediatric population. In our series, respiratory distress was rare, being MIS-C the most frequent cause of PICU admission related to SARS-CoV2. In most cases, the course of the disease was mild except in children with previous diseases | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ARDS | |
| 650 | 4 | |a MIS-C | |
| 650 | 4 | |a SARS-COV2 | |
| 650 | 4 | |a mechanical ventilation | |
| 650 | 4 | |a pediatric intensive care | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Belda Hofheinz, Sylvia |e verfasserin |4 aut | |
| 700 | 1 | |a Guitart Pardellans, Carmina |e verfasserin |4 aut | |
| 700 | 1 | |a García-Salido, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a de Carlos Vicente, Juan Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Cuervas-Mons Tejedor, Maite |e verfasserin |4 aut | |
| 700 | 1 | |a Hernández Yuste, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez Olmos, Ainhoa |e verfasserin |4 aut | |
| 700 | 1 | |a Morteruel Arizcuren, Elvira |e verfasserin |4 aut | |
| 700 | 1 | |a García-Besteiro, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Calvo Monge, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez Rubio, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Roca Pascual, David |e verfasserin |4 aut | |
| 700 | 1 | |a Bermúdez Barrezueta, Lorena |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez Padilla, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Huidobro Labarga, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Oulego-Erroz, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchíz Cárdenas, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Rey Galan, Corsino |e verfasserin |4 aut | |
| 700 | 1 | |a Holanda Peña, Maria Soledad |e verfasserin |4 aut | |
| 700 | 1 | |a González Navarro, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Cortés, Rafael González |e verfasserin |4 aut | |
| 700 | 0 | |a Spanish Pediatric Intensive Care Society working group on SARS-Cov2 infection |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric pulmonology |d 1993 |g 58(2023), 10 vom: 28. Okt., Seite 2916-2929 |w (DE-627)NLM012888230 |x 1099-0496 |7 nnns |
| 773 | 1 | 8 | |g volume:58 |g year:2023 |g number:10 |g day:28 |g month:10 |g pages:2916-2929 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/ppul.26613 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 58 |j 2023 |e 10 |b 28 |c 10 |h 2916-2929 | ||