Curcumin-loaded mesoporous silica nanoparticles for drug delivery : synthesis, biological assays and therapeutic potential - a review
This journal is © The Royal Society of Chemistry..
Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-delivery with other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable drug leakage and increase selectivity towards target tissues. This review summarizes the methods of Cur-loaded MSN synthesis and functionalization and their application in various diseases, and also highlights the potential of Cur-loaded MSNs as a promising drug delivery system.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
RSC advances - 13(2023), 32 vom: 19. Juli, Seite 22250-22267 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Iranshahy, Milad [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 27.07.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d3ra02772d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM359926738 |
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| 520 | |a This journal is © The Royal Society of Chemistry. | ||
| 520 | |a Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-delivery with other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable drug leakage and increase selectivity towards target tissues. This review summarizes the methods of Cur-loaded MSN synthesis and functionalization and their application in various diseases, and also highlights the potential of Cur-loaded MSNs as a promising drug delivery system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 700 | 1 | |a Aghili, Seyed Hadi |e verfasserin |4 aut | |
| 700 | 1 | |a Iranshahi, Mehrdad |e verfasserin |4 aut | |
| 700 | 1 | |a Nabavi, Seyed Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Saberi, Satar |e verfasserin |4 aut | |
| 700 | 1 | |a Filosa, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a Nezhad, Iman Farzam |e verfasserin |4 aut | |
| 700 | 1 | |a Hasanpour, Maede |e verfasserin |4 aut | |
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