Phomactinine, the First Nitrogen-Bearing Phomactin, Produced by Biatriospora sp. CBMAI 1333
Metabolomics analyses and improvement of growth conditions were applied toward diversification of phomactin terpenoids by the fungus Biatriospora sp. CBMAI 1333. Visualization of molecular networking results on Gephi assisted the observation of phomactin diversification and guided the isolation of new phomactin variants by applying a modified version of chemometrics based on a fractional factorial design. Consequentially, the first nitrogen-bearing phomactin, phomactinine (1), with a new rearranged carbon skeleton, was isolated and identified. The strategy combining metabolomics and chemometrics can be extended to include bioassay potency, structure novelty, and metabolic diversification connected or not to genomic analyses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
Journal of natural products - 86(2023), 8 vom: 25. Aug., Seite 2065-2072 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
da Silva Oliveira, Leandro [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 28.08.2023 Date Revised 06.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.jnatprod.3c00383 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Metabolomics analyses and improvement of growth conditions were applied toward diversification of phomactin terpenoids by the fungus Biatriospora sp. CBMAI 1333. Visualization of molecular networking results on Gephi assisted the observation of phomactin diversification and guided the isolation of new phomactin variants by applying a modified version of chemometrics based on a fractional factorial design. Consequentially, the first nitrogen-bearing phomactin, phomactinine (1), with a new rearranged carbon skeleton, was isolated and identified. The strategy combining metabolomics and chemometrics can be extended to include bioassay potency, structure novelty, and metabolic diversification connected or not to genomic analyses | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a de Amorim, Marcelo R |e verfasserin |4 aut | |
| 700 | 1 | |a Navarro-Vázquez, Armando |e verfasserin |4 aut | |
| 700 | 1 | |a Paz, Tiago A |e verfasserin |4 aut | |
| 700 | 1 | |a Freire, Vitor F |e verfasserin |4 aut | |
| 700 | 1 | |a Takaki, Mirelle |e verfasserin |4 aut | |
| 700 | 1 | |a Venâncio, Tiago |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Antonio G |e verfasserin |4 aut | |
| 700 | 1 | |a de Freitas Saito, Renata |e verfasserin |4 aut | |
| 700 | 1 | |a Chammas, Roger |e verfasserin |4 aut | |
| 700 | 1 | |a Berlinck, Roberto G S |e verfasserin |4 aut | |
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