Radioprotective effect of piperine, as a major component of black pepper, against radiation-induced colon injury : biochemical and histological studies
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Patients undergoing radiotherapy are prone to radiation-induced gastrointestinal injury. Piperine is an alkaloid component in black pepper with a unique chemopreventive activity against oxidative stress-related damage in healthy tissues. The purpose of this study was to investigate the effects of piperine on intestinal damage.
METHODS: In this study, mice were divided into eight groups: including the control, piperine (10, 25, and 50 mg/kg), radiation (6 Gy), and piperine+radiation (10, 25 and 50 mg/kg + 6 Gy) groups. The radioprotective effects of piperine were evaluated by biochemical (MDA, GSH, and PC) and histopathological assessments in colon tissues.
RESULTS: The 10 mg/kg dose of piperine significantly reduced the levels of oxidative stress biomarkers compared to the group that received only radiation. In addition, pre-treatment with 10 mg/kg piperine diminished the histopathological changes like vascular congestion in the submucosa, while the dose of 50 mg/kg led to the infiltration of inflammatory cells.
CONCLUSION: Based on this study, it is concluded that piperine, at low dose, with its antioxidant properties, could reduce the colon damage caused by radiation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Current radiopharmaceuticals - (2023) vom: 25. Juli |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Safarbalou, Asal [VerfasserIn] |
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| Links: |
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| Themen: |
Colon injury |
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| Anmerkungen: |
Date Revised 25.07.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/1874471016666230725112319 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359899838 |
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| 100 | 1 | |a Safarbalou, Asal |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Radioprotective effect of piperine, as a major component of black pepper, against radiation-induced colon injury |b biochemical and histological studies |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 25.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Patients undergoing radiotherapy are prone to radiation-induced gastrointestinal injury. Piperine is an alkaloid component in black pepper with a unique chemopreventive activity against oxidative stress-related damage in healthy tissues. The purpose of this study was to investigate the effects of piperine on intestinal damage | ||
| 520 | |a METHODS: In this study, mice were divided into eight groups: including the control, piperine (10, 25, and 50 mg/kg), radiation (6 Gy), and piperine+radiation (10, 25 and 50 mg/kg + 6 Gy) groups. The radioprotective effects of piperine were evaluated by biochemical (MDA, GSH, and PC) and histopathological assessments in colon tissues | ||
| 520 | |a RESULTS: The 10 mg/kg dose of piperine significantly reduced the levels of oxidative stress biomarkers compared to the group that received only radiation. In addition, pre-treatment with 10 mg/kg piperine diminished the histopathological changes like vascular congestion in the submucosa, while the dose of 50 mg/kg led to the infiltration of inflammatory cells | ||
| 520 | |a CONCLUSION: Based on this study, it is concluded that piperine, at low dose, with its antioxidant properties, could reduce the colon damage caused by radiation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colon injury | |
| 650 | 4 | |a Ionizing radiation | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Piperine | |
| 650 | 4 | |a Radiation | |
| 650 | 4 | |a Radioprotective | |
| 700 | 1 | |a Ebrahimi, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Talebpour Amiri, Fereshteh |e verfasserin |4 aut | |
| 700 | 1 | |a Hosseinimehr, Seyed Jalal |e verfasserin |4 aut | |
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