Optical coherence tomography angiography characteristics of retinochoroidal and optic nerve head microcirculation in cryptogenic organizing pneumonia
Copyright © 2023 Elsevier B.V. All rights reserved..
BACKGROUND: To assess retinochoroidal and optic nerve head microcirculation alterations in cryptogenic organizing pneumonia.
METHODS: Thirty cryptogenic organizing pneumonia patients in the resolution phase (group 1, 30 right eyes) and 33 healthy subjects (group 2, 33 right eyes) were compared. Patients had 40 mg/day corticosteroids for 8-10 days, and a pulmonary function test, which revealed only minimally restrictive ventilation features. After gathering demographic data, a comprehensive ophthalmological exam and optical coherence tomography angiography were performed three months following maximum disease resolution with corticosteroid therapy RESULTS: Groups 1 and 2 had mean ages of 54.37±14.87 and 49.61±12.36 years, respectively (P = 0.171). Despite the lack of statistical significance, superficial and deep capillary plexus vessel densities in all macular regions were lower in group 1, as were foveal avascular zone parameters (P>0.05). However, the outer retinal and choriocapillaris flows increased significantly in group 1, especially in select areas (P<0.001, for both). There were no significant differences in whole image (P = 0.346), inside disk (P = 0.438), or peripapillary (P = 0.185) optic nerve head vessel densities between the two groups; however, nasal (P<0.001) and inferior quadrant (P = 0.006) vessel densities differed significantly. Global retinal nerve fiber layer thickness did not differ significantly between groups 1 and 2 (112.83±14.71 versus 111.45±12.74 µm, respectively; P = 0.692). Group 1, however, had significantly higher superior, nasal, and inferior quadrant, and significantly lower temporal quadrant retinal nerve fiber layer thickness (P<0.001, for all).
CONCLUSIONS: Concerning the impact of probable cryptogenic organizing pneumonia-induced hypoxia on ocular tissues, optical coherence tomography angiography assessments of retinochoroidal and optic nerve head microcirculation could be employed as a biomarker for cerebral microcirculation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
Photodiagnosis and photodynamic therapy - 43(2023) vom: 24. Sept., Seite 103720 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Gobeka, Hamidu Hamisi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cryptogenic organizing pneumonia |
|---|
| Anmerkungen: |
Date Completed 08.09.2023 Date Revised 08.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.pdpdt.2023.103720 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM35988024X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM35988024X | ||
| 003 | DE-627 | ||
| 005 | 20231226081823.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pdpdt.2023.103720 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1199.xml |
| 035 | |a (DE-627)NLM35988024X | ||
| 035 | |a (NLM)37487811 | ||
| 035 | |a (PII)S1572-1000(23)00447-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Gobeka, Hamidu Hamisi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Optical coherence tomography angiography characteristics of retinochoroidal and optic nerve head microcirculation in cryptogenic organizing pneumonia |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.09.2023 | ||
| 500 | |a Date Revised 08.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: To assess retinochoroidal and optic nerve head microcirculation alterations in cryptogenic organizing pneumonia | ||
| 520 | |a METHODS: Thirty cryptogenic organizing pneumonia patients in the resolution phase (group 1, 30 right eyes) and 33 healthy subjects (group 2, 33 right eyes) were compared. Patients had 40 mg/day corticosteroids for 8-10 days, and a pulmonary function test, which revealed only minimally restrictive ventilation features. After gathering demographic data, a comprehensive ophthalmological exam and optical coherence tomography angiography were performed three months following maximum disease resolution with corticosteroid therapy RESULTS: Groups 1 and 2 had mean ages of 54.37±14.87 and 49.61±12.36 years, respectively (P = 0.171). Despite the lack of statistical significance, superficial and deep capillary plexus vessel densities in all macular regions were lower in group 1, as were foveal avascular zone parameters (P>0.05). However, the outer retinal and choriocapillaris flows increased significantly in group 1, especially in select areas (P<0.001, for both). There were no significant differences in whole image (P = 0.346), inside disk (P = 0.438), or peripapillary (P = 0.185) optic nerve head vessel densities between the two groups; however, nasal (P<0.001) and inferior quadrant (P = 0.006) vessel densities differed significantly. Global retinal nerve fiber layer thickness did not differ significantly between groups 1 and 2 (112.83±14.71 versus 111.45±12.74 µm, respectively; P = 0.692). Group 1, however, had significantly higher superior, nasal, and inferior quadrant, and significantly lower temporal quadrant retinal nerve fiber layer thickness (P<0.001, for all) | ||
| 520 | |a CONCLUSIONS: Concerning the impact of probable cryptogenic organizing pneumonia-induced hypoxia on ocular tissues, optical coherence tomography angiography assessments of retinochoroidal and optic nerve head microcirculation could be employed as a biomarker for cerebral microcirculation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cryptogenic organizing pneumonia | |
| 650 | 4 | |a Optic nerve head | |
| 650 | 4 | |a Optical coherence tomography angiography | |
| 650 | 4 | |a Retinal microcirculation | |
| 650 | 4 | |a Vessel density | |
| 650 | 7 | |a Photosensitizing Agents |2 NLM | |
| 700 | 1 | |a Balcı, Aydın |e verfasserin |4 aut | |
| 700 | 1 | |a Doğan, Mustafa |e verfasserin |4 aut | |
| 700 | 1 | |a Ay, İbrahim Ethem |e verfasserin |4 aut | |
| 700 | 1 | |a Yörükoğlu Kayabaş, Seray |e verfasserin |4 aut | |
| 700 | 1 | |a Büyükokudan, Uğur |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Photodiagnosis and photodynamic therapy |d 2004 |g 43(2023) vom: 24. Sept., Seite 103720 |w (DE-627)NLM182218406 |x 1873-1597 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2023 |g day:24 |g month:09 |g pages:103720 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.pdpdt.2023.103720 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2023 |b 24 |c 09 |h 103720 | ||