The memory impairment by hypothyroidism in mice is dependent on time-of-day and sex
Copyright © 2023 Elsevier B.V. All rights reserved..
Hypothyroidism is an endocrine-metabolic disorder, and as such it compromises a wide range of physiological functions. Memory deficits and, the most recently described, circadian rhythm disruption are among the impairments caused by thyroid dysfunctions. However, although highly likely, there is no evidence connecting these two effects of hypothyroidism. Here, we hypothesized the time-of-day interferes with the memory deficit caused by hypothyroidism. C57BL/6 J mice from both sexes were subjected to novel object recognition (NOR) task during the rest and active phases, corresponding to ZT 2-4 and 14-16, respectively (ZT: Zeitgeber time; ZT 0: lights on at 07:00 am). First, we showed that neither sex nor ZT altered object recognition memory (ORM) in euthyroid mice. Next, animals were divided into control (euthyroid) and hypothyroid [induced with methimazole (0.01%) and perchlorate (0.1%) treatment in the drinking water for 21 days] groups. Under euthyroid conditions, male and female mice recognized the novel object regardless of the time-of-day. However, hypothyroidism impaired ORM at rest phase (ZT 2-4) in both sexes. Surprisingly, in the active phase (ZT 14-16), the hypothyroid males performed the NOR, though a longer time to execute the task was required. In contrast, female hypothyroid mice showed a greater impairment in ORM. Our results suggest that hypothyroidism may disrupt the circadian rhythm in brain areas related to mnemonic processes since in euthyroid condition ORM is not affected by the time-of-day. Furthermore, our findings in an animal model indicate a pronounced deleterious effect of hypothyroidism in women.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:452 |
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| Enthalten in: |
Behavioural brain research - 452(2023) vom: 24. Aug., Seite 114595 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Barros, Carolina Fonseca de [VerfasserIn] |
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| Links: |
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| Themen: |
Hypothyroidism |
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| Anmerkungen: |
Date Completed 14.08.2023 Date Revised 14.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbr.2023.114595 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 4 | |a The memory impairment by hypothyroidism in mice is dependent on time-of-day and sex |
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| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Hypothyroidism is an endocrine-metabolic disorder, and as such it compromises a wide range of physiological functions. Memory deficits and, the most recently described, circadian rhythm disruption are among the impairments caused by thyroid dysfunctions. However, although highly likely, there is no evidence connecting these two effects of hypothyroidism. Here, we hypothesized the time-of-day interferes with the memory deficit caused by hypothyroidism. C57BL/6 J mice from both sexes were subjected to novel object recognition (NOR) task during the rest and active phases, corresponding to ZT 2-4 and 14-16, respectively (ZT: Zeitgeber time; ZT 0: lights on at 07:00 am). First, we showed that neither sex nor ZT altered object recognition memory (ORM) in euthyroid mice. Next, animals were divided into control (euthyroid) and hypothyroid [induced with methimazole (0.01%) and perchlorate (0.1%) treatment in the drinking water for 21 days] groups. Under euthyroid conditions, male and female mice recognized the novel object regardless of the time-of-day. However, hypothyroidism impaired ORM at rest phase (ZT 2-4) in both sexes. Surprisingly, in the active phase (ZT 14-16), the hypothyroid males performed the NOR, though a longer time to execute the task was required. In contrast, female hypothyroid mice showed a greater impairment in ORM. Our results suggest that hypothyroidism may disrupt the circadian rhythm in brain areas related to mnemonic processes since in euthyroid condition ORM is not affected by the time-of-day. Furthermore, our findings in an animal model indicate a pronounced deleterious effect of hypothyroidism in women | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Hypothyroidism | |
| 650 | 4 | |a Object recognition memory | |
| 650 | 4 | |a Sex dimorphism | |
| 650 | 4 | |a Thyroid hormones | |
| 650 | 4 | |a Time-of-day | |
| 700 | 1 | |a Guarnieri, Leonardo de Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Mansk, Lara Monteiro Zanetti |e verfasserin |4 aut | |
| 700 | 1 | |a Secio-Silva, Ayla |e verfasserin |4 aut | |
| 700 | 1 | |a Emrich, Felipe |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Maíza |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Walison Nunes da |e verfasserin |4 aut | |
| 700 | 1 | |a Peliciari-Garcia, Rodrigo Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Grace Schenatto |e verfasserin |4 aut | |
| 700 | 1 | |a Bargi-Souza, Paula |e verfasserin |4 aut | |
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