Dientamoeba fragilis associated with microbiome diversity changes in acute gastroenteritis patients
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved..
This study examined the correlation between intestinal protozoans and the bacterial microbiome in faecal samples collected from 463 patients in New Zealand who were diagnosed with gastroenteritis. In comparison to traditional microscopic diagnosis methods, Multiplexed-tandem PCR proved to be more effective in detecting intestinal parasites. Among the identified protozoans, Blastocystis sp. and Dientamoeba fragilis were the most prevalent. Notably, D. fragilis was significantly associated with an increase in the alpha-diversity of host prokaryotic microbes. Although the exact role of Blastocystis sp. and D. fragilis as the primary cause of gastroenteritis remains debatable, our data indicates a substantial correlation between these protozoans and the prokaryote microbiome of their hosts, particularly when compared to other protists or patients with gastroenteritis but no detectable parasitic cause. These findings underscore the significance of comprehending the contributions of intestinal protozoans, specifically D. fragilis, to the development of gastroenteritis and their potential implications for disease management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Parasitology international - 97(2023) vom: 10. Dez., Seite 102788 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Muhsin-Sharafaldine, M-R [VerfasserIn] |
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| Links: |
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| Themen: |
Blastocystis hominis |
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| Anmerkungen: |
Date Completed 06.09.2023 Date Revised 06.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.parint.2023.102788 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a This study examined the correlation between intestinal protozoans and the bacterial microbiome in faecal samples collected from 463 patients in New Zealand who were diagnosed with gastroenteritis. In comparison to traditional microscopic diagnosis methods, Multiplexed-tandem PCR proved to be more effective in detecting intestinal parasites. Among the identified protozoans, Blastocystis sp. and Dientamoeba fragilis were the most prevalent. Notably, D. fragilis was significantly associated with an increase in the alpha-diversity of host prokaryotic microbes. Although the exact role of Blastocystis sp. and D. fragilis as the primary cause of gastroenteritis remains debatable, our data indicates a substantial correlation between these protozoans and the prokaryote microbiome of their hosts, particularly when compared to other protists or patients with gastroenteritis but no detectable parasitic cause. These findings underscore the significance of comprehending the contributions of intestinal protozoans, specifically D. fragilis, to the development of gastroenteritis and their potential implications for disease management | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Cryptosporidium spp. | |
| 650 | 4 | |a Dientamoeba fragilis | |
| 650 | 4 | |a Gastroenteritis | |
| 650 | 4 | |a Giardia spp. | |
| 650 | 4 | |a Microbiome | |
| 700 | 1 | |a Abdel Rahman, L |e verfasserin |4 aut | |
| 700 | 1 | |a Suwanarusk, R |e verfasserin |4 aut | |
| 700 | 1 | |a Grant, J |e verfasserin |4 aut | |
| 700 | 1 | |a Parslow, G |e verfasserin |4 aut | |
| 700 | 1 | |a French, N |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, K S W |e verfasserin |4 aut | |
| 700 | 1 | |a Russell, B |e verfasserin |4 aut | |
| 700 | 1 | |a Morgan, X C |e verfasserin |4 aut | |
| 700 | 1 | |a Ussher, J E |e verfasserin |4 aut | |
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