Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil
© 2023. The Author(s)..
The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil.
Errataetall: | |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Nature communications - 14(2023), 1 vom: 21. Juli, Seite 4413 |
Sprache: |
Englisch |
---|
Links: |
---|
Themen: |
Journal Article |
---|
Anmerkungen: |
Date Completed 24.07.2023 Date Revised 27.07.2023 published: Electronic figshare: 10.6084/m9.figshare.22335331.v2 UpdateOf: medRxiv. 2023 Apr 03;:. - PMID 37034611 Citation Status MEDLINE |
---|
doi: |
10.1038/s41467-023-40099-y |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM359799590 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM359799590 | ||
003 | DE-627 | ||
005 | 20231226081641.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41467-023-40099-y |2 doi | |
028 | 5 | 2 | |a pubmed24n1199.xml |
035 | |a (DE-627)NLM359799590 | ||
035 | |a (NLM)37479700 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Xavier, Joilson |e verfasserin |4 aut | |
245 | 1 | 0 | |a Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 24.07.2023 | ||
500 | |a Date Revised 27.07.2023 | ||
500 | |a published: Electronic | ||
500 | |a figshare: 10.6084/m9.figshare.22335331.v2 | ||
500 | |a UpdateOf: medRxiv. 2023 Apr 03;:. - PMID 37034611 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023. The Author(s). | ||
520 | |a The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 7 | |a Nucleotides |2 NLM | |
700 | 1 | |a Alcantara, Luiz Carlos Junior |e verfasserin |4 aut | |
700 | 1 | |a Fonseca, Vagner |e verfasserin |4 aut | |
700 | 1 | |a Lima, Mauricio |e verfasserin |4 aut | |
700 | 1 | |a Castro, Emerson |e verfasserin |4 aut | |
700 | 1 | |a Fritsch, Hegger |e verfasserin |4 aut | |
700 | 1 | |a Oliveira, Carla |e verfasserin |4 aut | |
700 | 1 | |a Guimarães, Natalia |e verfasserin |4 aut | |
700 | 1 | |a Adelino, Talita |e verfasserin |4 aut | |
700 | 1 | |a Evaristo, Mariane |e verfasserin |4 aut | |
700 | 1 | |a Rodrigues, Evandra S |e verfasserin |4 aut | |
700 | 1 | |a Santos, Elaine Vieira |e verfasserin |4 aut | |
700 | 1 | |a de La-Roque, Debora |e verfasserin |4 aut | |
700 | 1 | |a de Moraes, Laise |e verfasserin |4 aut | |
700 | 1 | |a Tosta, Stephane |e verfasserin |4 aut | |
700 | 1 | |a Neto, Adelino |e verfasserin |4 aut | |
700 | 1 | |a Rosewell, Alexander |e verfasserin |4 aut | |
700 | 1 | |a Mendonça, Ana Flavia |e verfasserin |4 aut | |
700 | 1 | |a Leite, Anderson |e verfasserin |4 aut | |
700 | 1 | |a Vasconcelos, Andreza |e verfasserin |4 aut | |
700 | 1 | |a Silva de Mello, Arabela L |e verfasserin |4 aut | |
700 | 1 | |a Vasconcelos, Bergson |e verfasserin |4 aut | |
700 | 1 | |a Montalbano, Camila A |e verfasserin |4 aut | |
700 | 1 | |a Zanluca, Camila |e verfasserin |4 aut | |
700 | 1 | |a Freitas, Carla |e verfasserin |4 aut | |
700 | 1 | |a de Albuquerque, Carlos F C |e verfasserin |4 aut | |
700 | 1 | |a Duarte Dos Santos, Claudia Nunes |e verfasserin |4 aut | |
700 | 1 | |a Santos, Cleiton S |e verfasserin |4 aut | |
700 | 1 | |a Dos Santos, Cliomar Alves |e verfasserin |4 aut | |
700 | 1 | |a Gonçalves, Crhistinne C Maymone |e verfasserin |4 aut | |
700 | 1 | |a Teixeira, Dalane |e verfasserin |4 aut | |
700 | 1 | |a Neto, Daniel F L |e verfasserin |4 aut | |
700 | 1 | |a Cabral, Diego |e verfasserin |4 aut | |
700 | 1 | |a de Oliveira, Elaine C |e verfasserin |4 aut | |
700 | 1 | |a Noia Maciel, Ethel L |e verfasserin |4 aut | |
700 | 1 | |a Pereira, Felicidade Mota |e verfasserin |4 aut | |
700 | 1 | |a Iani, Felipe |e verfasserin |4 aut | |
700 | 1 | |a de Carvalho, Fernanda P |e verfasserin |4 aut | |
700 | 1 | |a Andrade, Gabriela |e verfasserin |4 aut | |
700 | 1 | |a Bezerra, Gabriela |e verfasserin |4 aut | |
700 | 1 | |a de Castro Lichs, Gislene G |e verfasserin |4 aut | |
700 | 1 | |a Pereira, Glauco Carvalho |e verfasserin |4 aut | |
700 | 1 | |a Barroso, Haline |e verfasserin |4 aut | |
700 | 1 | |a Franz, Helena Cristina Ferreira |e verfasserin |4 aut | |
700 | 1 | |a Ferreira, Hivylla |e verfasserin |4 aut | |
700 | 1 | |a Gomes, Iago |e verfasserin |4 aut | |
700 | 1 | |a Riediger, Irina N |e verfasserin |4 aut | |
700 | 1 | |a Rodrigues, Isabela |e verfasserin |4 aut | |
700 | 1 | |a de Siqueira, Isadora C |e verfasserin |4 aut | |
700 | 1 | |a Silva, Jacilane |e verfasserin |4 aut | |
700 | 1 | |a Rico, Jairo Mendez |e verfasserin |4 aut | |
700 | 1 | |a Lima, Jaqueline |e verfasserin |4 aut | |
700 | 1 | |a Abrantes, Jayra |e verfasserin |4 aut | |
700 | 1 | |a do Nascimento, Jean Phellipe M |e verfasserin |4 aut | |
700 | 1 | |a Wasserheit, Judith N |e verfasserin |4 aut | |
700 | 1 | |a Pastor, Julia |e verfasserin |4 aut | |
700 | 1 | |a de Magalhães, Jurandy J F |e verfasserin |4 aut | |
700 | 1 | |a Luz, Kleber Giovanni |e verfasserin |4 aut | |
700 | 1 | |a Lima Neto, Lidio G |e verfasserin |4 aut | |
700 | 1 | |a Frutuoso, Livia C V |e verfasserin |4 aut | |
700 | 1 | |a da Silva, Luana Barbosa |e verfasserin |4 aut | |
700 | 1 | |a Sena, Ludmila |e verfasserin |4 aut | |
700 | 1 | |a de Sousa, Luis Arthur F |e verfasserin |4 aut | |
700 | 1 | |a Pereira, Luiz Augusto |e verfasserin |4 aut | |
700 | 1 | |a Demarchi, Luiz |e verfasserin |4 aut | |
700 | 1 | |a Câmara, Magaly C B |e verfasserin |4 aut | |
700 | 1 | |a Astete, Marcela G |e verfasserin |4 aut | |
700 | 1 | |a Almiron, Maria |e verfasserin |4 aut | |
700 | 1 | |a Lima, Maricelia |e verfasserin |4 aut | |
700 | 1 | |a Umaki Zardin, Marina C S |e verfasserin |4 aut | |
700 | 1 | |a Presibella, Mayra M |e verfasserin |4 aut | |
700 | 1 | |a Falcão, Melissa B |e verfasserin |4 aut | |
700 | 1 | |a Gale, Michael |c Jr |e verfasserin |4 aut | |
700 | 1 | |a Freire, Naishe |e verfasserin |4 aut | |
700 | 1 | |a Marques, Nelson |e verfasserin |4 aut | |
700 | 1 | |a de Moura, Noely F O |e verfasserin |4 aut | |
700 | 1 | |a Almeida Da Silva, Pedro E |e verfasserin |4 aut | |
700 | 1 | |a Rabinowitz, Peter |e verfasserin |4 aut | |
700 | 1 | |a da Cunha, Rivaldo V |e verfasserin |4 aut | |
700 | 1 | |a Trinta, Karen S |e verfasserin |4 aut | |
700 | 1 | |a do Carmo Said, Rodrigo F |e verfasserin |4 aut | |
700 | 1 | |a Kato, Rodrigo |e verfasserin |4 aut | |
700 | 1 | |a Stabeli, Rodrigo |e verfasserin |4 aut | |
700 | 1 | |a de Jesus, Ronaldo |e verfasserin |4 aut | |
700 | 1 | |a Hans Santos, Roselene |e verfasserin |4 aut | |
700 | 1 | |a Kashima, Simone |e verfasserin |4 aut | |
700 | 1 | |a Slavov, Svetoslav N |e verfasserin |4 aut | |
700 | 1 | |a Andrade, Tamires |e verfasserin |4 aut | |
700 | 1 | |a Rocha, Themis |e verfasserin |4 aut | |
700 | 1 | |a Carneiro, Thiago |e verfasserin |4 aut | |
700 | 1 | |a Nardy, Vanessa |e verfasserin |4 aut | |
700 | 1 | |a da Silva, Vinicius |e verfasserin |4 aut | |
700 | 1 | |a Carvalho, Walterlene G |e verfasserin |4 aut | |
700 | 1 | |a Van Voorhis, Wesley C |e verfasserin |4 aut | |
700 | 1 | |a Araujo, Wildo N |e verfasserin |4 aut | |
700 | 1 | |a de Filippis, Ana M B |e verfasserin |4 aut | |
700 | 1 | |a Giovanetti, Marta |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 14(2023), 1 vom: 21. Juli, Seite 4413 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2023 |g number:1 |g day:21 |g month:07 |g pages:4413 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-023-40099-y |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2023 |e 1 |b 21 |c 07 |h 4413 |