Description of reinfection of joint prosthesis after 2-stage replacement (infection of the 2nd stage prosthesis) : A multicenter study
Copyright © 2023. Published by Elsevier España, S.L.U..
INTRODUCTION: Two-stage exchange is the gold standard in the surgical management of prosthetic joint infection (PJI). However, perioperative reinfections (RePJI) can occur to newly inserted prosthesis, which highlights the importance of an adequate antibiotic prophylaxis, although there is scarce evidence in this field. Our objective was to evaluate the characteristics of RePJI, its prognosis and the antibiotic prophylaxis that is commonly used in second-stage surgery.
METHODS: Multicentric retrospective observational study in Spanish hospitals including patients with RePJI between 2009 and 2018.
RESULTS: We included 92 patients with RePJI from 12 hospitals. The most frequent isolated microorganism was Staphylococcus epidermidis in 35 cases (38.5%); 61.1% of staphylococci were methiciliin-resistant. In 12 cases (13%), the same microoganism causing the primary PJI was isolated in RePJI. When comparing with the microbiology of primary PJI, there were more cases caused by Gram-negative bacteria (the most frequent was Pseudomonas spp.) and less by Gram-positive bacteria. Failure occured in 69 cases (75%). There were 43 different courses of antibiotic prophylaxis after the second-stage surgery; the most frequent was a unique preoperative cefazolin dose, but most patients received prophylaxis before and after the second-stage surgery (61 cases).
CONCLUSIONS: The most frequent microorganisms in RePJI are coagulase-negative staphylococci, although Gram-negative bacteria, especially Pseudomonas spp. are also common. There is a significant heterogeneity in antibiotic prophylaxis for a second-stage surgery. ReIPJI treatment has a high failure rate.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Enfermedades infecciosas y microbiologia clinica (English ed.) - (2023) vom: 19. Juli |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Barbero Allende, José M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antibiotic prophylaxis |
|---|
| Anmerkungen: |
Date Revised 21.07.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.eimce.2023.07.002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM359798195 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM359798195 | ||
| 003 | DE-627 | ||
| 005 | 20231226081639.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eimce.2023.07.002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1199.xml |
| 035 | |a (DE-627)NLM359798195 | ||
| 035 | |a (NLM)37479562 | ||
| 035 | |a (PII)S2529-993X(23)00196-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Barbero Allende, José M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Description of reinfection of joint prosthesis after 2-stage replacement (infection of the 2nd stage prosthesis) |b A multicenter study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 21.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023. Published by Elsevier España, S.L.U. | ||
| 520 | |a INTRODUCTION: Two-stage exchange is the gold standard in the surgical management of prosthetic joint infection (PJI). However, perioperative reinfections (RePJI) can occur to newly inserted prosthesis, which highlights the importance of an adequate antibiotic prophylaxis, although there is scarce evidence in this field. Our objective was to evaluate the characteristics of RePJI, its prognosis and the antibiotic prophylaxis that is commonly used in second-stage surgery | ||
| 520 | |a METHODS: Multicentric retrospective observational study in Spanish hospitals including patients with RePJI between 2009 and 2018 | ||
| 520 | |a RESULTS: We included 92 patients with RePJI from 12 hospitals. The most frequent isolated microorganism was Staphylococcus epidermidis in 35 cases (38.5%); 61.1% of staphylococci were methiciliin-resistant. In 12 cases (13%), the same microoganism causing the primary PJI was isolated in RePJI. When comparing with the microbiology of primary PJI, there were more cases caused by Gram-negative bacteria (the most frequent was Pseudomonas spp.) and less by Gram-positive bacteria. Failure occured in 69 cases (75%). There were 43 different courses of antibiotic prophylaxis after the second-stage surgery; the most frequent was a unique preoperative cefazolin dose, but most patients received prophylaxis before and after the second-stage surgery (61 cases) | ||
| 520 | |a CONCLUSIONS: The most frequent microorganisms in RePJI are coagulase-negative staphylococci, although Gram-negative bacteria, especially Pseudomonas spp. are also common. There is a significant heterogeneity in antibiotic prophylaxis for a second-stage surgery. ReIPJI treatment has a high failure rate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antibiotic prophylaxis | |
| 650 | 4 | |a Infección de prótesis | |
| 650 | 4 | |a Infección de prótesis articulares | |
| 650 | 4 | |a Profilaxis antibiótica | |
| 650 | 4 | |a Prosthesis-related infection | |
| 650 | 4 | |a Prosthetic-joint infection | |
| 700 | 1 | |a Gómez-Junyent, Joan |e verfasserin |4 aut | |
| 700 | 1 | |a Sorlí Redó, Lluisa |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Pardo, Dolors |e verfasserin |4 aut | |
| 700 | 1 | |a Murillo Rubio, Óscar |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández Sampedro, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Escudero-Sánchez, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a García Gutiérrez, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Portillo, M Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Sancho, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Rico Nieto, Alicia |e verfasserin |4 aut | |
| 700 | 1 | |a Guio Carrión, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Soriano, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a Morata Ruiz, Laura |e verfasserin |4 aut | |
| 700 | 0 | |a Grupo de Estudio de Infecciones Osteoarticulares (GEIO) de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Enfermedades infecciosas y microbiologia clinica (English ed.) |d 2012 |g (2023) vom: 19. Juli |w (DE-627)NLM220666776 |x 2529-993X |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:19 |g month:07 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.eimce.2023.07.002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 19 |c 07 | ||