Disturbance in the reconstitution of distinct T-cell subsets and the incidence of GvHD following allo-HSCT in pediatric patients with non-malignant hematological disorders
Copyright © 2023. Published by Elsevier B.V..
BACKGROUND: The reconstitution of different T-cell subsets following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is critical for efficient pathogen protection and the prevention of graft-versus-host disease (GvHD). In particular, studies have highlighted the importance of balanced ratios of regulatory T-cells (Tregs) and distinct functionally T-cells in preventing acute and chronic GvHD.
METHODS: We evaluated the regeneration of CD4 and CD8 T-cell subpopulations in nine pediatric patients with non-malignant disorders following allo-HSCT from a fully HLA-identical donor.
RESULTS: CD4 and CD8 T-cells were higher 12 months after the transplant but still lower than in healthy controls and pre-transplant. However, we found after allo-HSCT, central memory and effector memory cell subsets were the predominant phenotypes in the CD4 and CD8 T-cell populations, respectively. In patients who had developed acute GvHD, there was an increase in the frequency of TEMRA (effector memory T cells that re-express CD45RA) cells within the CD4 T-cell population. Meanwhile, in patients with chronic GvHD, we observed a decrease in Th1 cells in CD4 T-cells and effector memory cells within the CD8 T-cell population. In addition, we found decreased TEMRA cell subsets in CD4 and CD8 T-cell populations in chronic GvHD.
CONCLUSION: Our findings suggest a possible relationship between the influence of acute GvHD and its prevention on delayed CD4 T-cell reconstitution and, reciprocally, unbalanced regeneration of CD4 and CD8 T-cell subsets in the development of chronic GvHD.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:261 |
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Enthalten in: |
Immunology letters - 261(2023) vom: 24. Sept., Seite 25-36 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Bayegi, Shideh Namazi [VerfasserIn] |
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Links: |
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Themen: |
Allogeneic HSCT |
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Anmerkungen: |
Date Completed 21.08.2023 Date Revised 21.08.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.imlet.2023.07.008 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM359744591 |
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100 | 1 | |a Bayegi, Shideh Namazi |e verfasserin |4 aut | |
245 | 1 | 0 | |a Disturbance in the reconstitution of distinct T-cell subsets and the incidence of GvHD following allo-HSCT in pediatric patients with non-malignant hematological disorders |
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500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
520 | |a BACKGROUND: The reconstitution of different T-cell subsets following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is critical for efficient pathogen protection and the prevention of graft-versus-host disease (GvHD). In particular, studies have highlighted the importance of balanced ratios of regulatory T-cells (Tregs) and distinct functionally T-cells in preventing acute and chronic GvHD | ||
520 | |a METHODS: We evaluated the regeneration of CD4 and CD8 T-cell subpopulations in nine pediatric patients with non-malignant disorders following allo-HSCT from a fully HLA-identical donor | ||
520 | |a RESULTS: CD4 and CD8 T-cells were higher 12 months after the transplant but still lower than in healthy controls and pre-transplant. However, we found after allo-HSCT, central memory and effector memory cell subsets were the predominant phenotypes in the CD4 and CD8 T-cell populations, respectively. In patients who had developed acute GvHD, there was an increase in the frequency of TEMRA (effector memory T cells that re-express CD45RA) cells within the CD4 T-cell population. Meanwhile, in patients with chronic GvHD, we observed a decrease in Th1 cells in CD4 T-cells and effector memory cells within the CD8 T-cell population. In addition, we found decreased TEMRA cell subsets in CD4 and CD8 T-cell populations in chronic GvHD | ||
520 | |a CONCLUSION: Our findings suggest a possible relationship between the influence of acute GvHD and its prevention on delayed CD4 T-cell reconstitution and, reciprocally, unbalanced regeneration of CD4 and CD8 T-cell subsets in the development of chronic GvHD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Allogeneic HSCT | |
650 | 4 | |a GvHD | |
650 | 4 | |a T-cell | |
700 | 1 | |a Hamidieh, Amir Ali |e verfasserin |4 aut | |
700 | 1 | |a Behfar, Maryam |e verfasserin |4 aut | |
700 | 1 | |a Bozorgmehr, Mahmood |e verfasserin |4 aut | |
700 | 1 | |a Saghazadeh, Amene |e verfasserin |4 aut | |
700 | 1 | |a Tajik, Nader |e verfasserin |4 aut | |
700 | 1 | |a Delbandi, Ali-Akbar |e verfasserin |4 aut | |
700 | 1 | |a Zavareh, Farzaneh Tofighi |e verfasserin |4 aut | |
700 | 1 | |a Delavari, Samaneh |e verfasserin |4 aut | |
700 | 1 | |a Shekarabi, Mehdi |e verfasserin |4 aut | |
700 | 1 | |a Rezaei, Nima |e verfasserin |4 aut | |
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