Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared with controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland-innervating neurons. Depletion of macrophages in the SCG prevented disease-associated denervation of the pineal gland and restored physiological melatonin secretion. Our data identify the mechanism by which diurnal rhythmicity in cardiac disease is disturbed and suggest a target for therapeutic intervention.
| Errataetall: |
CommentIn: Nat Rev Neurosci. 2023 Oct;24(10):589. - PMID 37553550 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:381 |
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| Enthalten in: |
Science (New York, N.Y.) - 381(2023), 6655 vom: 21. Juli, Seite 285-290 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ziegler, Karin A [VerfasserIn] |
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Date Completed 28.07.2023 Date Revised 15.03.2024 published: Print-Electronic CommentIn: Nat Rev Neurosci. 2023 Oct;24(10):589. - PMID 37553550 Citation Status MEDLINE |
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| doi: |
10.1126/science.abn6366 |
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| 500 | |a CommentIn: Nat Rev Neurosci. 2023 Oct;24(10):589. - PMID 37553550 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared with controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland-innervating neurons. Depletion of macrophages in the SCG prevented disease-associated denervation of the pineal gland and restored physiological melatonin secretion. Our data identify the mechanism by which diurnal rhythmicity in cardiac disease is disturbed and suggest a target for therapeutic intervention | ||
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