Towards a Systemic Concept of the Brain Ishemia Stroke : Monte Carlo Driven in Silico Model
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: The work proposes a new mathematical model of dynamic processes of a typical spatially heterogeneous biological system, and sets and solves a mathematical problem of modeling the dynamics of the system of neurovascular units of the brain in conditions of ischemic stroke. There is a description of only a small number of mathematical models of stroke in the literature. This model is being studied and a numerical and software implementation of the corresponding mathematical problem is proposed.
METHODS: This work is the first attempt ever aiming to employ a Monte Carlo computational approach for In Silico simulation of the most critical parameters in molecular and cellular pathogenesis of the brain ischemic stroke. In this work, a new mathematical model of the development of ischemic stroke is proposed in the form of a discrete model based on neurovascular units (NVU) as elements.
RESULTS: As a result of testing the program with the assignment of empirically selected coefficients, data were obtained on the evolution of the states of the lattice of the cellular automaton of the model for the spread of stroke in a region of the brain tissue. A resulting new theoretical model of the particular pathologically altered biosystem might be taken as a promising tool for further studies in neurology; general pathology and cell biology.
CONCLUSION: For the first time, a mathematical model has been constructed that allows us to represent the spatial dynamics of the development of the affected area in ischemic stroke of the brain, taking into account neurovascular units as single morphofunctional structures.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
CNS & neurological disorders drug targets - (2023) vom: 19. Juli |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fursov, Valentin V [VerfasserIn] |
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| Links: |
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| Themen: |
Biosystem theoretical models |
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| Anmerkungen: |
Date Revised 20.07.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/1871527322666230719111903 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359696147 |
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| 100 | 1 | |a Fursov, Valentin V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Towards a Systemic Concept of the Brain Ishemia Stroke |b Monte Carlo Driven in Silico Model |
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| 500 | |a Date Revised 20.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: The work proposes a new mathematical model of dynamic processes of a typical spatially heterogeneous biological system, and sets and solves a mathematical problem of modeling the dynamics of the system of neurovascular units of the brain in conditions of ischemic stroke. There is a description of only a small number of mathematical models of stroke in the literature. This model is being studied and a numerical and software implementation of the corresponding mathematical problem is proposed | ||
| 520 | |a METHODS: This work is the first attempt ever aiming to employ a Monte Carlo computational approach for In Silico simulation of the most critical parameters in molecular and cellular pathogenesis of the brain ischemic stroke. In this work, a new mathematical model of the development of ischemic stroke is proposed in the form of a discrete model based on neurovascular units (NVU) as elements | ||
| 520 | |a RESULTS: As a result of testing the program with the assignment of empirically selected coefficients, data were obtained on the evolution of the states of the lattice of the cellular automaton of the model for the spread of stroke in a region of the brain tissue. A resulting new theoretical model of the particular pathologically altered biosystem might be taken as a promising tool for further studies in neurology; general pathology and cell biology | ||
| 520 | |a CONCLUSION: For the first time, a mathematical model has been constructed that allows us to represent the spatial dynamics of the development of the affected area in ischemic stroke of the brain, taking into account neurovascular units as single morphofunctional structures | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Monte Carlo method | |
| 650 | 4 | |a biosystem theoretical models | |
| 650 | 4 | |a brain ischemic disorders | |
| 650 | 4 | |a cellular automata | |
| 650 | 4 | |a in silico | |
| 650 | 4 | |a ischemic stroke | |
| 650 | 4 | |a neurovascular unit | |
| 700 | 1 | |a Ananiev, Alexander V |e verfasserin |4 aut | |
| 700 | 1 | |a Kuznetsov, Dmitry A |e verfasserin |4 aut | |
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