Proteasome as a Drug Target in Trypanosomatid Diseases
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Some diseases caused by trypanosomatid parasites, like Leishmaniasis, Chagas Disease, and Human African Trypanosomiasis (HTA), are challenging to manage, mainly concerning pharmacological therapy because they are associated with vulnerable populations. Unfortunately, there is a lack of significant investments in the search for new drugs. Therefore, one of the strategies to aid the discovery of new drugs is to identify and inhibit molecular targets essential to the parasite's survival, such as the proteasome, which degrades most proteins in the parasite cells. Our study has presented several proteasome inhibitors with various pharmacophoric cores, and two of them, 5, and 13, have stood out in the clinical phase of treatment for leishmaniasis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Current drug targets - 24(2023), 10 vom: 30., Seite 781-789 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Silva, Mariana Luiza [VerfasserIn] |
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| Links: |
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| Themen: |
Chagas |
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| Anmerkungen: |
Date Completed 23.08.2023 Date Revised 26.08.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1389450124666230719104147 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Some diseases caused by trypanosomatid parasites, like Leishmaniasis, Chagas Disease, and Human African Trypanosomiasis (HTA), are challenging to manage, mainly concerning pharmacological therapy because they are associated with vulnerable populations. Unfortunately, there is a lack of significant investments in the search for new drugs. Therefore, one of the strategies to aid the discovery of new drugs is to identify and inhibit molecular targets essential to the parasite's survival, such as the proteasome, which degrades most proteins in the parasite cells. Our study has presented several proteasome inhibitors with various pharmacophoric cores, and two of them, 5, and 13, have stood out in the clinical phase of treatment for leishmaniasis | ||
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