Targets Involved in Skin Aging and Photoaging and their Possible Inhibitors : A Mini-review
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Skin aging is a natural process resulting from intrinsic (hormonal and genetic) and extrinsic (environmental) factors. Photoaging occurs due to prolonged exposure of the skin to ultraviolet radiation, accounting for 80% of facial aging.
INTRODUCTION: Characteristics of aging skin include reduced elasticity, the appearance of fine wrinkles, uneven tone, and dryness. Clinical signs of photoaging involve the presence of deeper wrinkles, rough texture, dyschromia and a greater loss of elasticity compared to chronological aging.
METHODS: This work reported several scientific articles that used computational techniques, such as molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to identify natural products and their derivatives against skin aging and photoaging.
RESULTS: The in silico analyses carried out by the researchers predicted the binding affinity and interactions of the natural products with the targets matrix metalloproteinase-1, matrix metalloproteinase- 3, matrix metalloproteinase-9 and tyrosinase. Furthermore, some studies have reported the stability of the protein-ligand complex and the physicochemical properties of the studied compounds. Finally, this research proposes promising molecules against the targets.
CONCLUSION: Thus, studies like this one are relevant to guide new research related to skin aging and photoaging.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Current drug targets - 24(2023), 10 vom: 30., Seite 797-815 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Moura, Jéssica Paiva [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 23.08.2023 Date Revised 26.08.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1389450124666230719105849 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM359696031 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM359696031 | ||
| 003 | DE-627 | ||
| 005 | 20231226081426.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1389450124666230719105849 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1198.xml |
| 035 | |a (DE-627)NLM359696031 | ||
| 035 | |a (NLM)37469150 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Moura, Jéssica Paiva |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Targets Involved in Skin Aging and Photoaging and their Possible Inhibitors |b A Mini-review |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.08.2023 | ||
| 500 | |a Date Revised 26.08.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Skin aging is a natural process resulting from intrinsic (hormonal and genetic) and extrinsic (environmental) factors. Photoaging occurs due to prolonged exposure of the skin to ultraviolet radiation, accounting for 80% of facial aging | ||
| 520 | |a INTRODUCTION: Characteristics of aging skin include reduced elasticity, the appearance of fine wrinkles, uneven tone, and dryness. Clinical signs of photoaging involve the presence of deeper wrinkles, rough texture, dyschromia and a greater loss of elasticity compared to chronological aging | ||
| 520 | |a METHODS: This work reported several scientific articles that used computational techniques, such as molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to identify natural products and their derivatives against skin aging and photoaging | ||
| 520 | |a RESULTS: The in silico analyses carried out by the researchers predicted the binding affinity and interactions of the natural products with the targets matrix metalloproteinase-1, matrix metalloproteinase- 3, matrix metalloproteinase-9 and tyrosinase. Furthermore, some studies have reported the stability of the protein-ligand complex and the physicochemical properties of the studied compounds. Finally, this research proposes promising molecules against the targets | ||
| 520 | |a CONCLUSION: Thus, studies like this one are relevant to guide new research related to skin aging and photoaging | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a MMP-1 | |
| 650 | 4 | |a MMP-3 | |
| 650 | 4 | |a MMP-9 | |
| 650 | 4 | |a Skin aging | |
| 650 | 4 | |a molecular docking | |
| 650 | 4 | |a photoaging | |
| 650 | 4 | |a tyrosinase | |
| 700 | 1 | |a de Moura Fernandes, Érika Paiva |e verfasserin |4 aut | |
| 700 | 1 | |a Lustoza Rodrigues, Teresa Carolliny Moreira |e verfasserin |4 aut | |
| 700 | 1 | |a Messias Monteiro, Alex France |e verfasserin |4 aut | |
| 700 | 1 | |a de Sousa, Natália Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos, Aline Matilde Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Scotti, Marcus Tullius |e verfasserin |4 aut | |
| 700 | 1 | |a Scotti, Luciana |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current drug targets |d 2000 |g 24(2023), 10 vom: 30., Seite 797-815 |w (DE-627)NLM113669291 |x 1873-5592 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:10 |g day:30 |g pages:797-815 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1389450124666230719105849 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 10 |b 30 |h 797-815 | ||