Lignocellulosic biomass-based glycoconjugates for diverse biotechnological applications
Copyright © 2023 Elsevier Inc. All rights reserved..
Glycoconjugates are the ubiquitous components of mammalian cells, mainly synthesized by covalent bonds of carbohydrates to other biomolecules such as proteins and lipids, with a wide range of potential applications in novel vaccines, therapeutic peptides and antibodies (Ab). Considering the emerging developments in glycoscience, renewable production of glycoconjugates is of importance and lignocellulosic biomass (LCB) is a potential source of carbohydrates to produce synthetic glycoconjugates in a sustainable pathway. In this review, recent advances in glycobiology aiming on glycoconjugates production is presented together with the recent and cutting-edge advances in the therapeutic properties and application of glycoconjugates, including therapeutic glycoproteins, glycosaminoglycans (GAGs), and nutraceuticals, emphasizing the integral role of glycosylation in their function and efficacy. Special emphasis is given towards the potential exploration of carbon neutral feedstocks, in which LCB has an emerging role. Techniques for extraction and recovery of mono- and oligosaccharides from LCB are critically discussed and influence of the heterogeneous nature of the feedstocks and different methods for recovery of these sugars in the development of the customized glycoconjugates is explored. Although reports on the use of LCB for the production of glycoconjugates are scarce, this review sets clear that the potential of LCB as a source for the production of valuable glycoconjugates cannot be underestimated and encourages that future research should focus on refining the existing methodologies and exploring new approaches to fully realize the potential of LCB in glycoconjugate production.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
|---|---|
| Enthalten in: |
Biotechnology advances - 68(2023) vom: 15. Nov., Seite 108209 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rodrigues Reis, Cristiano E [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
11132-73-3 |
|---|
| Anmerkungen: |
Date Completed 13.09.2023 Date Revised 14.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.biotechadv.2023.108209 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM359683258 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM359683258 | ||
| 003 | DE-627 | ||
| 005 | 20231226081410.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.biotechadv.2023.108209 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1198.xml |
| 035 | |a (DE-627)NLM359683258 | ||
| 035 | |a (NLM)37467868 | ||
| 035 | |a (PII)S0734-9750(23)00116-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rodrigues Reis, Cristiano E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lignocellulosic biomass-based glycoconjugates for diverse biotechnological applications |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.09.2023 | ||
| 500 | |a Date Revised 14.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Glycoconjugates are the ubiquitous components of mammalian cells, mainly synthesized by covalent bonds of carbohydrates to other biomolecules such as proteins and lipids, with a wide range of potential applications in novel vaccines, therapeutic peptides and antibodies (Ab). Considering the emerging developments in glycoscience, renewable production of glycoconjugates is of importance and lignocellulosic biomass (LCB) is a potential source of carbohydrates to produce synthetic glycoconjugates in a sustainable pathway. In this review, recent advances in glycobiology aiming on glycoconjugates production is presented together with the recent and cutting-edge advances in the therapeutic properties and application of glycoconjugates, including therapeutic glycoproteins, glycosaminoglycans (GAGs), and nutraceuticals, emphasizing the integral role of glycosylation in their function and efficacy. Special emphasis is given towards the potential exploration of carbon neutral feedstocks, in which LCB has an emerging role. Techniques for extraction and recovery of mono- and oligosaccharides from LCB are critically discussed and influence of the heterogeneous nature of the feedstocks and different methods for recovery of these sugars in the development of the customized glycoconjugates is explored. Although reports on the use of LCB for the production of glycoconjugates are scarce, this review sets clear that the potential of LCB as a source for the production of valuable glycoconjugates cannot be underestimated and encourages that future research should focus on refining the existing methodologies and exploring new approaches to fully realize the potential of LCB in glycoconjugate production | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Glycoconjugates | |
| 650 | 4 | |a Immunologicals | |
| 650 | 4 | |a Lignocellulosics | |
| 650 | 4 | |a Renewable sugars | |
| 650 | 4 | |a Therapeutics | |
| 650 | 7 | |a lignocellulose |2 NLM | |
| 650 | 7 | |a 11132-73-3 |2 NLM | |
| 650 | 7 | |a Glycoconjugates |2 NLM | |
| 650 | 7 | |a Glycoproteins |2 NLM | |
| 650 | 7 | |a Carbohydrates |2 NLM | |
| 700 | 1 | |a Milessi, Thais Suzane |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Márcio Daniel Nicodemos |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Akhilesh Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Mohanakrishna, Gunda |e verfasserin |4 aut | |
| 700 | 1 | |a Aminabhavi, Tejraj M |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, P Senthil |e verfasserin |4 aut | |
| 700 | 1 | |a Chandel, Anuj K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biotechnology advances |d 1983 |g 68(2023) vom: 15. Nov., Seite 108209 |w (DE-627)NLM083784144 |x 1873-1899 |7 nnns |
| 773 | 1 | 8 | |g volume:68 |g year:2023 |g day:15 |g month:11 |g pages:108209 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.biotechadv.2023.108209 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 68 |j 2023 |b 15 |c 11 |h 108209 | ||