Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved..
STUDY DESIGN: This was as clinical retrospective study.
OBJECTIVES: We sought to evaluate the characteristics of Pediatric intramedullary spinal cord tumors (PISCTs) and to identify differences between pediatric and adult intramedullary spinal cord tumors.
SUMMARY OF BACKGROUND DATA: PISCTs represent a rare clinical entity with limited evidence-base in the literature.
METHODS: This study is a subanalysis of the retrospective multicenter observational study authorized by the Neurospinal Society of Japan, including consecutive patients with spinal intramedullary tumors treated surgically at 58 institutions between 2009 and 2020. Data on 1080 intramedullary spinal cord tumors were obtained, consisting of 91 pediatric and 939 adult patients. Survival was compared using Cox hazard regression while clinical differences were evaluated using multivariable logistic regression that controlled for confounders.
RESULTS: Pediatric patients had a shorter overall, and progression-free, survival than adults. Pediatric patients with ISCTs were likely to have scoliosis [odds ratio (OR) = 6.49, 95% CI: 2.26-18.7], short preoperative symptom duration (OR = 0.99, 95% CI: 0.98-0.99), lower incidence of paresthesia (OR = 0.41, 95% CI: 0.22-0.77), higher incidence of paresis (OR = 2.10, 95% CI: 1.01-4.35), histopathology of astrocytoma (OR = 2.97, 95% CI: 1.19-7.43), and postoperative functional deterioration upon discharge (OR = 2.83, 95% CI: 1.43-5.58). Age was not a statistically significant prognostic factor of overall survival among the pediatric cohort.
CONCLUSION: We found that the clinical characteristics of ISCTs differed between pediatric and adult patients. In terms of histopathological types, astrocytoma was most common in pediatric patients. ISCT occurring at an early age may not be an indicator for poor prognosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Spine - 49(2023), 2 vom: 15. Jan., Seite 107-115 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Umebayashi, Daisuke [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 18.12.2023 Date Revised 18.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/BRS.0000000000004775 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359666779 |
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| 100 | 1 | |a Umebayashi, Daisuke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 18.12.2023 | ||
| 500 | |a Date Revised 18.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a STUDY DESIGN: This was as clinical retrospective study | ||
| 520 | |a OBJECTIVES: We sought to evaluate the characteristics of Pediatric intramedullary spinal cord tumors (PISCTs) and to identify differences between pediatric and adult intramedullary spinal cord tumors | ||
| 520 | |a SUMMARY OF BACKGROUND DATA: PISCTs represent a rare clinical entity with limited evidence-base in the literature | ||
| 520 | |a METHODS: This study is a subanalysis of the retrospective multicenter observational study authorized by the Neurospinal Society of Japan, including consecutive patients with spinal intramedullary tumors treated surgically at 58 institutions between 2009 and 2020. Data on 1080 intramedullary spinal cord tumors were obtained, consisting of 91 pediatric and 939 adult patients. Survival was compared using Cox hazard regression while clinical differences were evaluated using multivariable logistic regression that controlled for confounders | ||
| 520 | |a RESULTS: Pediatric patients had a shorter overall, and progression-free, survival than adults. Pediatric patients with ISCTs were likely to have scoliosis [odds ratio (OR) = 6.49, 95% CI: 2.26-18.7], short preoperative symptom duration (OR = 0.99, 95% CI: 0.98-0.99), lower incidence of paresthesia (OR = 0.41, 95% CI: 0.22-0.77), higher incidence of paresis (OR = 2.10, 95% CI: 1.01-4.35), histopathology of astrocytoma (OR = 2.97, 95% CI: 1.19-7.43), and postoperative functional deterioration upon discharge (OR = 2.83, 95% CI: 1.43-5.58). Age was not a statistically significant prognostic factor of overall survival among the pediatric cohort | ||
| 520 | |a CONCLUSION: We found that the clinical characteristics of ISCTs differed between pediatric and adult patients. In terms of histopathological types, astrocytoma was most common in pediatric patients. ISCT occurring at an early age may not be an indicator for poor prognosis | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Naito, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Kurokawa, Ryu |e verfasserin |4 aut | |
| 700 | 1 | |a Endo, Toshiki |e verfasserin |4 aut | |
| 700 | 1 | |a Mizuno, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshimaru, Minoru |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Phyo |e verfasserin |4 aut | |
| 700 | 1 | |a Hida, Kazutoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Takami, Toshihiro |e verfasserin |4 aut | |
| 700 | 0 | |a Neurospinal Society of Japan Intramedullary Tumor Study Collaborators |e verfasserin |4 aut | |
| 700 | 1 | |a Hara, Masahito |e investigator |4 oth | |
| 700 | 1 | |a Aoyama, Masahiro |e investigator |4 oth | |
| 700 | 1 | |a Sugawara, Taku |e investigator |4 oth | |
| 700 | 1 | |a Shimizu, Hiroaki |e investigator |4 oth | |
| 700 | 1 | |a Ogihara, Kotaro |e investigator |4 oth | |
| 700 | 1 | |a Sugawara, Atsushi |e investigator |4 oth | |
| 700 | 1 | |a Itoki, Kazushige |e investigator |4 oth | |
| 700 | 1 | |a Matsui, Seiji |e investigator |4 oth | |
| 700 | 1 | |a Shigekawa, Seiji |e investigator |4 oth | |
| 700 | 1 | |a Kunihiro, Noritsugu |e investigator |4 oth | |
| 700 | 1 | |a Yamamoto, Shinji |e investigator |4 oth | |
| 700 | 1 | |a Yasuhara, Takao |e investigator |4 oth | |
| 700 | 1 | |a Iwasaki, Motoyuki |e investigator |4 oth | |
| 700 | 1 | |a Ueda, Shigeo |e investigator |4 oth | |
| 700 | 1 | |a Miyoshi, Yasuyuki |e investigator |4 oth | |
| 700 | 1 | |a Hayashi, Hideki |e investigator |4 oth | |
| 700 | 1 | |a Noriyuki, Nakayama |e investigator |4 oth | |
| 700 | 1 | |a Iwama, Toru |e investigator |4 oth | |
| 700 | 1 | |a Nakagawa, Hiroshi |e investigator |4 oth | |
| 700 | 1 | |a Sumiyoshi, Manabu |e investigator |4 oth | |
| 700 | 1 | |a Hijikata, Yasukazu |e investigator |4 oth | |
| 700 | 1 | |a Uchikado, Hisaaki |e investigator |4 oth | |
| 700 | 1 | |a Fukuda, Hitoshi |e investigator |4 oth | |
| 700 | 1 | |a Nakai, Tomoaki |e investigator |4 oth | |
| 700 | 1 | |a Sasayama, Takashi |e investigator |4 oth | |
| 700 | 1 | |a Mishima, Kazuhiko |e investigator |4 oth | |
| 700 | 1 | |a Inoue, Tomoo |e investigator |4 oth | |
| 700 | 1 | |a Yano, Shunsuke |e investigator |4 oth | |
| 700 | 1 | |a Sasamori, Toru |e investigator |4 oth | |
| 700 | 1 | |a Mikuni, Nobuhiro |e investigator |4 oth | |
| 700 | 1 | |a Akiyama, Yukinori |e investigator |4 oth | |
| 700 | 1 | |a Hara, Tsuyoshi |e investigator |4 oth | |
| 700 | 1 | |a Gondo, Gakuji |e investigator |4 oth | |
| 700 | 1 | |a Yoshida, Mitsuhiro |e investigator |4 oth | |
| 700 | 1 | |a Komatani, Hideki |e investigator |4 oth | |
| 700 | 1 | |a Takahashi, Yuichi |e investigator |4 oth | |
| 700 | 1 | |a Ito, Kiyoshi |e investigator |4 oth | |
| 700 | 1 | |a Goto, Hisaharu |e investigator |4 oth | |
| 700 | 1 | |a Yasuhiro, Node |e investigator |4 oth | |
| 700 | 1 | |a Watanabe, Mizuki |e investigator |4 oth | |
| 700 | 1 | |a Ito, Yasunobu |e investigator |4 oth | |
| 700 | 1 | |a Hirano, Yoshitaka |e investigator |4 oth | |
| 700 | 1 | |a Tominaga, Teiji |e investigator |4 oth | |
| 700 | 1 | |a Takami, Hirokazu |e investigator |4 oth | |
| 700 | 1 | |a Karakama, Jun |e investigator |4 oth | |
| 700 | 1 | |a Ohashi, Hiroki |e investigator |4 oth | |
| 700 | 1 | |a Harada, Naoyuki |e investigator |4 oth | |
| 700 | 1 | |a Shingo, Tetsuro |e investigator |4 oth | |
| 700 | 1 | |a Kawajiri, Satoshi |e investigator |4 oth | |
| 700 | 1 | |a Yamauchi, Tomohiro |e investigator |4 oth | |
| 700 | 1 | |a Uno, Tetsuji |e investigator |4 oth | |
| 700 | 1 | |a Takai, Keisuke |e investigator |4 oth | |
| 700 | 1 | |a Fujimoto, So |e investigator |4 oth | |
| 700 | 1 | |a Otake, Yasufumi |e investigator |4 oth | |
| 700 | 1 | |a Takeshima, Yasuhiro |e investigator |4 oth | |
| 700 | 1 | |a Nakase, Hiroyuki |e investigator |4 oth | |
| 700 | 1 | |a Saito, Akihiko |e investigator |4 oth | |
| 700 | 1 | |a Morimoto, Daijiro |e investigator |4 oth | |
| 700 | 1 | |a Kim, Kyongsong |e investigator |4 oth | |
| 700 | 1 | |a Ohtonari, Tatsuya |e investigator |4 oth | |
| 700 | 1 | |a Kageyama, Hiroto |e investigator |4 oth | |
| 700 | 1 | |a Mitsuhara, Takafumi |e investigator |4 oth | |
| 700 | 1 | |a Kuromi, Yosuke |e investigator |4 oth | |
| 700 | 1 | |a Takahashi, Toshiyuki |e investigator |4 oth | |
| 700 | 1 | |a Kanematsu, Ryo |e investigator |4 oth | |
| 700 | 1 | |a Inoue, Tatsushi |e investigator |4 oth | |
| 700 | 1 | |a Muto, Jun |e investigator |4 oth | |
| 700 | 1 | |a Seki, Toshitaka |e investigator |4 oth | |
| 700 | 1 | |a Yamazaki, Kazuyoshi |e investigator |4 oth | |
| 700 | 1 | |a Koyanagi, Izumi |e investigator |4 oth | |
| 700 | 1 | |a Yoshifuji, Kazuhisa |e investigator |4 oth | |
| 700 | 1 | |a Fujimoto, Masashi |e investigator |4 oth | |
| 700 | 1 | |a Nishikawa, Misao |e investigator |4 oth | |
| 700 | 1 | |a Yagi, Takashi |e investigator |4 oth | |
| 700 | 1 | |a Kinouchi, Hiroyuki |e investigator |4 oth | |
| 700 | 1 | |a Murata, Hidetoshi |e investigator |4 oth | |
| 700 | 1 | |a Kitayama, Mari |e investigator |4 oth | |
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