The association between drug pricing and drug shortage in Saudi Arabia : a retrospective database analysis
© 2023. The Author(s)..
BACKGROUND: Previous studies have suggested that drug pricing could contribute to drug shortages; however, there is limited quantitative assessment of this potential causal association. This retrospective database analysis aimed to investigate the association between drug prices and drug shortage incidents in Saudi Arabia.
METHODS: This was a retrospective database analysis study. Drugs with shortage notifications sent to the Saudi Food and Drug Authority (SFDA) between January 2017 and December 2020 were included. Each drug's foreign-to-Saudi price ratio (FTSPR) was calculated by dividing the mean international price by the Saudi price. Drugs were categorized into three groups based on their FTSPR: Group 1 (FTSPR > 1), Group 2 (FTSPR = 1), and Group 3 (FTSPR < 1). The primary outcome was the ratio of mean counts (mCR) between the three groups, with Group 3 serving as the control group. The analysis was adjusted for the measured confounders using a negative binomial regression model.
RESULTS: A total of 900 drugs were included in the study, with 348 in Group 1, 345 in Group 2, and 209 in Group 3. The mean count in Group 1 was higher compared to Group 3 (mCR: 1.88; 95% confidence interval [CI] 1.24 to 2.83), while the mean counts between Group 2 and Group 3 were comparable (mCR: 1.39; 95% CI 0.92 to 2.09).
CONCLUSIONS: Our findings indicate an association between drug shortage incidents and higher prices of drugs outside Saudi Arabia. Further studies are needed to explore this causal relationship in different contexts.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Journal of pharmaceutical policy and practice - 16(2023), 1 vom: 18. Juli, Seite 91 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alowairdhi, Mohammad A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 21.07.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s40545-023-00591-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359648797 |
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| 100 | 1 | |a Alowairdhi, Mohammad A |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association between drug pricing and drug shortage in Saudi Arabia |b a retrospective database analysis |
| 264 | 1 | |c 2023 | |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Previous studies have suggested that drug pricing could contribute to drug shortages; however, there is limited quantitative assessment of this potential causal association. This retrospective database analysis aimed to investigate the association between drug prices and drug shortage incidents in Saudi Arabia | ||
| 520 | |a METHODS: This was a retrospective database analysis study. Drugs with shortage notifications sent to the Saudi Food and Drug Authority (SFDA) between January 2017 and December 2020 were included. Each drug's foreign-to-Saudi price ratio (FTSPR) was calculated by dividing the mean international price by the Saudi price. Drugs were categorized into three groups based on their FTSPR: Group 1 (FTSPR > 1), Group 2 (FTSPR = 1), and Group 3 (FTSPR < 1). The primary outcome was the ratio of mean counts (mCR) between the three groups, with Group 3 serving as the control group. The analysis was adjusted for the measured confounders using a negative binomial regression model | ||
| 520 | |a RESULTS: A total of 900 drugs were included in the study, with 348 in Group 1, 345 in Group 2, and 209 in Group 3. The mean count in Group 1 was higher compared to Group 3 (mCR: 1.88; 95% confidence interval [CI] 1.24 to 2.83), while the mean counts between Group 2 and Group 3 were comparable (mCR: 1.39; 95% CI 0.92 to 2.09) | ||
| 520 | |a CONCLUSIONS: Our findings indicate an association between drug shortage incidents and higher prices of drugs outside Saudi Arabia. Further studies are needed to explore this causal relationship in different contexts | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Drug shortage | |
| 650 | 4 | |a Pricing | |
| 650 | 4 | |a Regulatory science | |
| 700 | 1 | |a Alhussain, Fatimah H |e verfasserin |4 aut | |
| 700 | 1 | |a Alomran, Maha I |e verfasserin |4 aut | |
| 700 | 1 | |a Almadani, Ohoud A |e verfasserin |4 aut | |
| 700 | 1 | |a Alkhammash, Norah A |e verfasserin |4 aut | |
| 700 | 1 | |a Alyabes, Shayma F |e verfasserin |4 aut | |
| 700 | 1 | |a Alharbi, Sultan A |e verfasserin |4 aut | |
| 700 | 1 | |a Almudaiheem, Esraa A |e verfasserin |4 aut | |
| 700 | 1 | |a Alhaider, Reem A |e verfasserin |4 aut | |
| 700 | 1 | |a Alhassan, Sara A |e verfasserin |4 aut | |
| 700 | 1 | |a Almuallem, Zainab A |e verfasserin |4 aut | |
| 700 | 1 | |a Algain, Nuha |e verfasserin |4 aut | |
| 700 | 1 | |a Alshehri, Abdulaziz O |e verfasserin |4 aut | |
| 700 | 1 | |a Alshammari, Thamir M |e verfasserin |4 aut | |
| 700 | 1 | |a Althunian, Turki A |e verfasserin |4 aut | |
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