Strongyloides stercoralis infection : an underlying cause of invasive bacterial infections of enteric origin. Results from a prospective cross-sectional study of a northern Italian tertiary hospital
© 2023. The Author(s)..
PURPOSE OF THE STUDY: We assessed the prevalence of S. stercoralis in a cohort of inpatients with invasive bacterial infections of enteric origin to investigate whether the parasite may facilitate these bacterial infections even in the absence of larval hyperproliferation.
METHODS: We performed a prospective cross-sectional study in a hospital in northern Italy. Subjects admitted due to invasive bacterial infection of enteric origin and potential previous exposure to S. stercoralis were systematically enrolled over a period of 10 months. S. stercoralis infection was investigated with an in-house PCR on a single stool sample and with at least one serological method (in-house IFAT and/or ELISA Bordier). Univariate, bi-variate and logistic regression analyses were performed.
RESULTS: Strongyloidiasis was diagnosed in 14/57 patients (24.6%; 95% confidence interval 14.1-37.8%) of which 10 were Italians (10/49, 20.4%) and 4 were migrants (4/8, 50.0%). Stool PCR was performed in 43/57 patients (75.4%) and no positive results were obtained. Strongyloidiasis was found to be significantly associated (p ≤ 0.05) with male gender, long international travels to areas at higher endemicity, deep extra-intestinal infectious localization and solid tumors. In the logistic regression model, increased risk remained for the variables deep extra-intestinal infectious localization and oncologic malignancy.
CONCLUSIONS: Our findings suggest a new role of chronic strongyloidiasis in favoring invasive bacterial infections of enteric origin even in the absence of evident larval dissemination outside the intestinal lumen. Further well-designed studies should be conducted to confirm our results, and possibly establish the underlying mechanisms.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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Enthalten in: |
Infection - 51(2023), 5 vom: 18. Okt., Seite 1541-1548 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gardini, Giulia [VerfasserIn] |
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Links: |
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Themen: |
Enteric sepsis |
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Anmerkungen: |
Date Completed 03.10.2023 Date Revised 05.10.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s15010-023-02072-1 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM359633870 |
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520 | |a © 2023. The Author(s). | ||
520 | |a PURPOSE OF THE STUDY: We assessed the prevalence of S. stercoralis in a cohort of inpatients with invasive bacterial infections of enteric origin to investigate whether the parasite may facilitate these bacterial infections even in the absence of larval hyperproliferation | ||
520 | |a METHODS: We performed a prospective cross-sectional study in a hospital in northern Italy. Subjects admitted due to invasive bacterial infection of enteric origin and potential previous exposure to S. stercoralis were systematically enrolled over a period of 10 months. S. stercoralis infection was investigated with an in-house PCR on a single stool sample and with at least one serological method (in-house IFAT and/or ELISA Bordier). Univariate, bi-variate and logistic regression analyses were performed | ||
520 | |a RESULTS: Strongyloidiasis was diagnosed in 14/57 patients (24.6%; 95% confidence interval 14.1-37.8%) of which 10 were Italians (10/49, 20.4%) and 4 were migrants (4/8, 50.0%). Stool PCR was performed in 43/57 patients (75.4%) and no positive results were obtained. Strongyloidiasis was found to be significantly associated (p ≤ 0.05) with male gender, long international travels to areas at higher endemicity, deep extra-intestinal infectious localization and solid tumors. In the logistic regression model, increased risk remained for the variables deep extra-intestinal infectious localization and oncologic malignancy | ||
520 | |a CONCLUSIONS: Our findings suggest a new role of chronic strongyloidiasis in favoring invasive bacterial infections of enteric origin even in the absence of evident larval dissemination outside the intestinal lumen. Further well-designed studies should be conducted to confirm our results, and possibly establish the underlying mechanisms | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Enteric sepsis | |
650 | 4 | |a Intestinal bacteria | |
650 | 4 | |a Intestinal helminths | |
650 | 4 | |a Intestinal parasitosis | |
650 | 4 | |a Strongyloides stercoralis | |
650 | 4 | |a Strongyloidiasis | |
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700 | 1 | |a Gurrieri, Francesca |e verfasserin |4 aut | |
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700 | 1 | |a Cattaneo, Chiara |e verfasserin |4 aut | |
700 | 1 | |a Marchese, Valentina |e verfasserin |4 aut | |
700 | 1 | |a Piccinelli, Giorgio |e verfasserin |4 aut | |
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700 | 1 | |a Matteelli, Alberto |e verfasserin |4 aut | |
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