Effects of platelet-rich fibrin and dexamethasone on nerve regeneration after acute facial-nerve injury
BACKGROUND: Acute facial-nerve injury.
OBJECTIVE: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration.
MATERIALS AND METHODS: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks.
RESULTS: The mean eye-closure movement score in Group B was significantly higher than that in Group F (p < .001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p = .001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p < .001). Furthermore, an improvement in nerve ultrastructure was observed in Group B.
CONCLUSION: PRF application has a positive effect on nerve recovery after anastomosis.
SIGNIFICANCE: Contribute to the literature to improve nerve regeneration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
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| Enthalten in: |
Acta oto-laryngologica - 143(2023), 7 vom: 15. Juli, Seite 623-629 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Işik, Ünal Gökalp [VerfasserIn] |
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| Links: |
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| Themen: |
7S5I7G3JQL |
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| Anmerkungen: |
Date Completed 02.11.2023 Date Revised 02.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/00016489.2023.2233085 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359533884 |
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| 500 | |a Date Revised 02.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Acute facial-nerve injury | ||
| 520 | |a OBJECTIVE: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration | ||
| 520 | |a MATERIALS AND METHODS: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks | ||
| 520 | |a RESULTS: The mean eye-closure movement score in Group B was significantly higher than that in Group F (p < .001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p = .001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p < .001). Furthermore, an improvement in nerve ultrastructure was observed in Group B | ||
| 520 | |a CONCLUSION: PRF application has a positive effect on nerve recovery after anastomosis | ||
| 520 | |a SIGNIFICANCE: Contribute to the literature to improve nerve regeneration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dexamethasone | |
| 650 | 4 | |a facial nerve | |
| 650 | 4 | |a nerve recovery | |
| 650 | 4 | |a platelet-rich fibrin | |
| 650 | 7 | |a Dexamethasone |2 NLM | |
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| 700 | 1 | |a Sarikçioğlu, Levent |e verfasserin |4 aut | |
| 700 | 1 | |a Sonbay Yilmaz, Nevreste Didem |e verfasserin |4 aut | |
| 700 | 1 | |a Yüksel, Yeşim |e verfasserin |4 aut | |
| 700 | 1 | |a Senirli, Rezarta Taga |e verfasserin |4 aut | |
| 700 | 1 | |a Yildiz, Muhammet |e verfasserin |4 aut | |
| 700 | 1 | |a Selçuk, Ömer Tarik |e verfasserin |4 aut | |
| 700 | 1 | |a Çetinkaya, Erdem Atalay |e verfasserin |4 aut | |
| 700 | 1 | |a Eyigör, Hülya |e verfasserin |4 aut | |
| 700 | 1 | |a Gür, Özer Erdem |e verfasserin |4 aut | |
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