Effect of melatonin on otoprotection in rodents : a systematic review with meta-analysis
Copyright © 2023 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier España S.L.U. All rights reserved..
OBJECTIVES: To determinate the otoprotective efficacy of melatonin.in experimental models of rodents through a systematic review of the literature.
METHODS: Altogether, 154 articles were found in four databases. The PICOS strategy (Population, Intervention, Comparison, and Outcome) was used to define the eligibility criteria. Studies that met the inclusion criteria for the second step were included in a qualitative synthesis. Each study type was analyzed with the CAMARADES quality of assessment's checklist and the SYRCLE RoBS risk of bias.
RESULTS: Seven articles were selected, and four were included in the meta-analysis. It was possible to obtain seven outcomes according to the standard auditory frequencies presented among the studies, considering a minimum of three standard frequencies. The outcomes analyzed were for the frequencies of 1500, 2000, 3000, 4000, 5000, 6000, and 8000 Hz.
CONCLUSION: Melatonin can provide protection against the ototoxic effects of cisplatin and aminoglycosides at 5000 Hz, 6000 Hz, and 8000 Hz, thereby minimizing the reduction in Otoacustic Emissions (OAE) amplitude. The same effect was not observed in the lower frequencies. Despite the limited number of studies that were evaluated, the results appeared consistent in higher frequencies. However, the methodology of the available studies did not meet the necessary methodological rigor that promotes the safe replicability of these studies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
Brazilian journal of otorhinolaryngology - 89(2023), 5 vom: 01. Sept., Seite 101288 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Assumpção, Natália Lombardi [VerfasserIn] |
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| Links: |
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| Themen: |
Cisplatin |
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| Anmerkungen: |
Date Completed 02.11.2023 Date Revised 02.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bjorl.2023.101288 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359519040 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier España S.L.U. All rights reserved. | ||
| 520 | |a OBJECTIVES: To determinate the otoprotective efficacy of melatonin.in experimental models of rodents through a systematic review of the literature | ||
| 520 | |a METHODS: Altogether, 154 articles were found in four databases. The PICOS strategy (Population, Intervention, Comparison, and Outcome) was used to define the eligibility criteria. Studies that met the inclusion criteria for the second step were included in a qualitative synthesis. Each study type was analyzed with the CAMARADES quality of assessment's checklist and the SYRCLE RoBS risk of bias | ||
| 520 | |a RESULTS: Seven articles were selected, and four were included in the meta-analysis. It was possible to obtain seven outcomes according to the standard auditory frequencies presented among the studies, considering a minimum of three standard frequencies. The outcomes analyzed were for the frequencies of 1500, 2000, 3000, 4000, 5000, 6000, and 8000 Hz | ||
| 520 | |a CONCLUSION: Melatonin can provide protection against the ototoxic effects of cisplatin and aminoglycosides at 5000 Hz, 6000 Hz, and 8000 Hz, thereby minimizing the reduction in Otoacustic Emissions (OAE) amplitude. The same effect was not observed in the lower frequencies. Despite the limited number of studies that were evaluated, the results appeared consistent in higher frequencies. However, the methodology of the available studies did not meet the necessary methodological rigor that promotes the safe replicability of these studies | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Melatonin | |
| 650 | 4 | |a Otoprotection | |
| 650 | 4 | |a Ototoxic agents | |
| 650 | 4 | |a Rodents | |
| 650 | 7 | |a Melatonin |2 NLM | |
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| 650 | 7 | |a Cisplatin |2 NLM | |
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| 700 | 1 | |a Araújo, Juliana Gusmão de |e verfasserin |4 aut | |
| 700 | 1 | |a Serra, Lucieny Silva Martins |e verfasserin |4 aut | |
| 700 | 1 | |a Ribeiro, Vanessa Veis |e verfasserin |4 aut | |
| 700 | 1 | |a Sampaio, Maria Luiza Queiroz |e verfasserin |4 aut | |
| 700 | 1 | |a Caram, Andressa Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Sampaio, André Luiz Lopes |e verfasserin |4 aut | |
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