The relation of sarcopenia and disability in multiple sclerosis
Copyright © 2023. Published by Elsevier B.V..
BACKGROUND: The relation of sarcopenia and disability in MS is unknown.
OBJECTIVE: To investigate the relation of temporal muscle thickness (TMT) and disability.
METHODS: A cohort of 132 people who presented with a clinically isolated syndrome (CIS) suggestive of MS at a mean age of 30.0 years, were prospectively followed clinically and with MRI over 30-years. TMT and expanded disability status scale (EDSS) were assessed at baseline, one- five- ten- fourteen- twenty- and thirty-year follow-up.
RESULTS: At 30-years, 27 participants remained classified as having had a CIS, 34 converted to relapsing remitting MS, 26 to secondary progressive MS, and 16 had died due to MS. Using linear mixed effect models with subject nested in time, greater annualized TMT-thinning was seen in individuals who developed MS (-0.04 mm/a, 95%CI: -0.07 to -0.01, p = 0.023). In those who converted to MS, a thinner TMT was reached at 14- (p = 0.008), 20- (p = 0.002) and 30-years (p< 0.001). TMT was negatively correlated with EDSS at 20-years (R=-0.18, p = 0.032) and 30-years (R-0.244, p = 0.005). Longitudinally, TMT at earlier timepoints was not predictive for 30-year clinical outcomes.
CONCLUSION: TMT thinning is accelerated in MS and correlated with disability in later disease stages, but is not predictive of future disability.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
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| Enthalten in: |
Multiple sclerosis and related disorders - 77(2023) vom: 30. Sept., Seite 104855 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Haider, Lukas [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 11.09.2023 Date Revised 11.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.msard.2023.104855 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359428576 |
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| 245 | 1 | 4 | |a The relation of sarcopenia and disability in multiple sclerosis |
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| 500 | |a Date Revised 11.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
| 520 | |a BACKGROUND: The relation of sarcopenia and disability in MS is unknown | ||
| 520 | |a OBJECTIVE: To investigate the relation of temporal muscle thickness (TMT) and disability | ||
| 520 | |a METHODS: A cohort of 132 people who presented with a clinically isolated syndrome (CIS) suggestive of MS at a mean age of 30.0 years, were prospectively followed clinically and with MRI over 30-years. TMT and expanded disability status scale (EDSS) were assessed at baseline, one- five- ten- fourteen- twenty- and thirty-year follow-up | ||
| 520 | |a RESULTS: At 30-years, 27 participants remained classified as having had a CIS, 34 converted to relapsing remitting MS, 26 to secondary progressive MS, and 16 had died due to MS. Using linear mixed effect models with subject nested in time, greater annualized TMT-thinning was seen in individuals who developed MS (-0.04 mm/a, 95%CI: -0.07 to -0.01, p = 0.023). In those who converted to MS, a thinner TMT was reached at 14- (p = 0.008), 20- (p = 0.002) and 30-years (p< 0.001). TMT was negatively correlated with EDSS at 20-years (R=-0.18, p = 0.032) and 30-years (R-0.244, p = 0.005). Longitudinally, TMT at earlier timepoints was not predictive for 30-year clinical outcomes | ||
| 520 | |a CONCLUSION: TMT thinning is accelerated in MS and correlated with disability in later disease stages, but is not predictive of future disability | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Long-term outcome | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Sarcopenia | |
| 650 | 4 | |a Temporal muscle thickness | |
| 700 | 1 | |a Chung, Karen K |e verfasserin |4 aut | |
| 700 | 1 | |a Mangesius, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Furtner, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccarelli, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Chard, Declan T |e verfasserin |4 aut | |
| 700 | 1 | |a Barkhof, Frederik |e verfasserin |4 aut | |
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