A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023
An outbreak of Ralstonia mannitolilytica bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with R. mannitolilytica. Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with R. mannitolilytica infections (attack rate = 34%; 95% confidence interval: 22.1-47.4). Discontinuation of the contaminated urokinase terminated the outbreak.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 28(2023), 28 vom: 12. Juli |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fabricci, Massimiliano [VerfasserIn] |
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| Links: |
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| Themen: |
Bacteraemia |
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| Anmerkungen: |
Date Completed 17.07.2023 Date Revised 12.01.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.2807/1560-7917.ES.2023.28.28.2300328 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359411363 |
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| 245 | 1 | 2 | |a A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023 |
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| 500 | |a Date Revised 12.01.2024 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a An outbreak of Ralstonia mannitolilytica bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with R. mannitolilytica. Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with R. mannitolilytica infections (attack rate = 34%; 95% confidence interval: 22.1-47.4). Discontinuation of the contaminated urokinase terminated the outbreak | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Outbreak | |
| 650 | 4 | |a Ralstonia | |
| 650 | 4 | |a bacteraemia | |
| 650 | 4 | |a catheter | |
| 650 | 4 | |a dialysis | |
| 650 | 4 | |a mannitolilytica | |
| 650 | 4 | |a sepsis | |
| 650 | 4 | |a urokinase | |
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| 700 | 1 | |a Trinca, Anaïs |e verfasserin |4 aut | |
| 700 | 1 | |a Talotti, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Busetti, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Fotakis, Emmanouil Alexandros |e verfasserin |4 aut | |
| 700 | 1 | |a Merakou, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Koncan, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Ghiotti, Annachiara |e verfasserin |4 aut | |
| 700 | 1 | |a Negri, Camilla |e verfasserin |4 aut | |
| 700 | 1 | |a Di Maso, Vittorio |e verfasserin |4 aut | |
| 700 | 1 | |a Bosco, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a Antonelli, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Coppi, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Rossolini, Gian Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Giuliani, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Scarpis, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Gregoretti, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Licastro, Danilo |e verfasserin |4 aut | |
| 700 | 1 | |a Luzzati, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Costantino, Venera |e verfasserin |4 aut | |
| 700 | 0 | |a multidisciplinary working group |e verfasserin |4 aut | |
| 700 | 0 | |a Multidisciplinary working group |e verfasserin |4 aut | |
| 700 | 1 | |a Barbone, Fabio |e investigator |4 oth | |
| 700 | 1 | |a Bedina, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Bottacin, Tania |e investigator |4 oth | |
| 700 | 1 | |a Cara, Alice |e investigator |4 oth | |
| 700 | 1 | |a Cipriani, Leda |e investigator |4 oth | |
| 700 | 1 | |a Cocconi, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Cordova Luna, Maryluz |e investigator |4 oth | |
| 700 | 1 | |a D'Agaro, Pierlanfranco |e investigator |4 oth | |
| 700 | 1 | |a Di Bella, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Di Santolo, Manuela |e investigator |4 oth | |
| 700 | 1 | |a Dolce, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Fais, Roberta |e investigator |4 oth | |
| 700 | 1 | |a Fontana, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Guerra, Antonietta |e investigator |4 oth | |
| 700 | 1 | |a Lucarelli, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Maraglino, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Martone, Massimiliano |e investigator |4 oth | |
| 700 | 1 | |a Maurel, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Mian, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Monticelli, Jacopo |e investigator |4 oth | |
| 700 | 1 | |a Pagotto, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Parenzan, Ketty |e investigator |4 oth | |
| 700 | 1 | |a Pezzotti, Patrizio |e investigator |4 oth | |
| 700 | 1 | |a Pipoli, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Roni, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Sabbatucci, Michela |e investigator |4 oth | |
| 700 | 1 | |a Sartor, Assunta |e investigator |4 oth | |
| 700 | 1 | |a Schincariol, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Tascini, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Tosto, Massimiliano |e investigator |4 oth | |
| 700 | 1 | |a Turello, Gabriele |e investigator |4 oth | |
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