Improvement of Light Chain Proximal Tubulopathy without Crystals in IgGλ-type Monoclonal Gammopathy of Undetermined Significance Using Bortezomib and Dexamethasone
A 70-year-old woman with acute kidney injury, a high serum Creatinine (Cr) level (3.91 mg/dL), and proteinuria (protein/Cr ratio 1.59 g/gCr) was admitted. Serum IgG λ-type and urinary λ-type M proteins were observed. A bone marrow examination indicated monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy showed distended proximal tubular cells, and immunofluorescence identified tissue positive for proximal tubular cell λ light chains. Electron microscopy identified fibril-like structures in the lysosomes. The patient was diagnosed with light chain proximal tubulopathy without crystals in IgG λ-type MGUS and treated with bortezomib and dexamethasone therapy, which improved her renal function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 63(2024), 5 vom: 01. März, Seite 693-698 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tsuyuki, Tomohisa [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 02.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.1835-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359389481 |
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| 520 | |a A 70-year-old woman with acute kidney injury, a high serum Creatinine (Cr) level (3.91 mg/dL), and proteinuria (protein/Cr ratio 1.59 g/gCr) was admitted. Serum IgG λ-type and urinary λ-type M proteins were observed. A bone marrow examination indicated monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy showed distended proximal tubular cells, and immunofluorescence identified tissue positive for proximal tubular cell λ light chains. Electron microscopy identified fibril-like structures in the lysosomes. The patient was diagnosed with light chain proximal tubulopathy without crystals in IgG λ-type MGUS and treated with bortezomib and dexamethasone therapy, which improved her renal function | ||
| 650 | 4 | |a Case Reports | |
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| 650 | 4 | |a light chain proximal tubulopathy without crystals | |
| 650 | 4 | |a monoclonal gammopathy of renal significance | |
| 650 | 4 | |a monoclonal gammopathy of undetermined significance | |
| 650 | 4 | |a paraprotein-related kidney disease | |
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| 700 | 1 | |a Uramatsu, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Masatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ishi, Takuma |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuji, Kiyokazu |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Katafuchi, Eisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nakayama, Toshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Uesugi, Noriko |e verfasserin |4 aut | |
| 700 | 1 | |a Muta, Kumiko |e verfasserin |4 aut | |
| 700 | 1 | |a Nishino, Tomoya |e verfasserin |4 aut | |
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