Psychosocial functioning of adult siblings of Dutch very long-term survivors of childhood cancer : DCCSS-LATER 2 psycho-oncology study
© 2023 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd..
OBJECTIVE: To describe psychosocial outcomes among adult siblings of very long-term childhood cancer survivors (CCS), to compare these outcomes to reference populations and to identify factors associated with siblings' psychosocial outcomes.
METHODS: Siblings of survivors (diagnosed <18 years old, between 1963 and 2001, >5 years since diagnosis) of the Dutch Childhood Cancer Survivor Study DCCSS-LATER cohort were invited to complete questionnaires on HRQoL (TNO-AZL Questionnaire for Adult's HRQoL), anxiety/depression (Hospital Anxiety and Depression Scale), post-traumatic stress (Self-Rating Scale for Post-traumatic Stress Disorder), self-esteem (Rosenberg Self-Esteem Scale) and benefit and burden (Benefit and Burden Scale for Children). Outcomes were compared to a reference group if available, using Mann-Whitney U and chi-Square tests. Associations of siblings' sociodemographic and CCS' cancer-related characteristics with the outcomes were assessed with mixed model analysis.
RESULTS: Five hundred five siblings (response rate 34%, 64% female, mean age 37.5, mean time since diagnosis 29.5) of 412 CCS participated. Siblings had comparable HRQoL, anxiety and self-esteem to references with no or small differences (r = 0.08-0.15, p < 0.05) and less depression. Proportions of symptomatic PTSD were very small (0.4%-0.6%). Effect sizes of associations of siblings' sociodemographic and CCS cancer-related characteristics were mostly small to medium (β = 0.19-0.67, p < 0.05) and no clear trend was found in the studied associated factors for worse outcomes.
CONCLUSIONS: On the very long-term, siblings do not have impaired psychosocial functioning compared to references. Cancer-related factors seem not to impact siblings' psychosocial functioning. Early support and education remain essential to prevent long-term consequences.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Psycho-oncology - 32(2023), 9 vom: 11. Sept., Seite 1401-1411 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 08.09.2023 Date Revised 14.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/pon.6191 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359351476 |
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| 100 | 1 | |a Joosten, Mala M H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Psychosocial functioning of adult siblings of Dutch very long-term survivors of childhood cancer |b DCCSS-LATER 2 psycho-oncology study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 08.09.2023 | ||
| 500 | |a Date Revised 14.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: To describe psychosocial outcomes among adult siblings of very long-term childhood cancer survivors (CCS), to compare these outcomes to reference populations and to identify factors associated with siblings' psychosocial outcomes | ||
| 520 | |a METHODS: Siblings of survivors (diagnosed <18 years old, between 1963 and 2001, >5 years since diagnosis) of the Dutch Childhood Cancer Survivor Study DCCSS-LATER cohort were invited to complete questionnaires on HRQoL (TNO-AZL Questionnaire for Adult's HRQoL), anxiety/depression (Hospital Anxiety and Depression Scale), post-traumatic stress (Self-Rating Scale for Post-traumatic Stress Disorder), self-esteem (Rosenberg Self-Esteem Scale) and benefit and burden (Benefit and Burden Scale for Children). Outcomes were compared to a reference group if available, using Mann-Whitney U and chi-Square tests. Associations of siblings' sociodemographic and CCS' cancer-related characteristics with the outcomes were assessed with mixed model analysis | ||
| 520 | |a RESULTS: Five hundred five siblings (response rate 34%, 64% female, mean age 37.5, mean time since diagnosis 29.5) of 412 CCS participated. Siblings had comparable HRQoL, anxiety and self-esteem to references with no or small differences (r = 0.08-0.15, p < 0.05) and less depression. Proportions of symptomatic PTSD were very small (0.4%-0.6%). Effect sizes of associations of siblings' sociodemographic and CCS cancer-related characteristics were mostly small to medium (β = 0.19-0.67, p < 0.05) and no clear trend was found in the studied associated factors for worse outcomes | ||
| 520 | |a CONCLUSIONS: On the very long-term, siblings do not have impaired psychosocial functioning compared to references. Cancer-related factors seem not to impact siblings' psychosocial functioning. Early support and education remain essential to prevent long-term consequences | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a benefit and burden | |
| 650 | 4 | |a health-related quality of life | |
| 650 | 4 | |a pediatric oncology | |
| 650 | 4 | |a post-traumatic stress | |
| 650 | 4 | |a psycho-oncology | |
| 650 | 4 | |a psychosocial outcomes | |
| 650 | 4 | |a siblings | |
| 650 | 4 | |a survivors of childhood cancer | |
| 700 | 1 | |a van Gorp, Marloes |e verfasserin |4 aut | |
| 700 | 1 | |a van Dijk, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Kremer, Leontien C M |e verfasserin |4 aut | |
| 700 | 1 | |a van Dulmen-den Broeder, Eline |e verfasserin |4 aut | |
| 700 | 1 | |a Tissing, Wim J E |e verfasserin |4 aut | |
| 700 | 1 | |a Loonen, Jacqueline J |e verfasserin |4 aut | |
| 700 | 1 | |a van der Pal, Helena J H |e verfasserin |4 aut | |
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| 700 | 1 | |a Bresters, Dorine |e verfasserin |4 aut | |
| 700 | 1 | |a Louwerens, Marloes |e verfasserin |4 aut | |
| 700 | 1 | |a Neggers, Sebastian J C C M |e verfasserin |4 aut | |
| 700 | 1 | |a van der Heiden-van der Loo, Margriet |e verfasserin |4 aut | |
| 700 | 1 | |a Maurice-Stam, Heleen |e verfasserin |4 aut | |
| 700 | 1 | |a Grootenhuis, Martha A |e verfasserin |4 aut | |
| 700 | 0 | |a Dutch LATER study group |e verfasserin |4 aut | |
| 700 | 1 | |a Versluys, Birgitta |e investigator |4 oth | |
| 700 | 1 | |a van Leeuwen, Flora |e investigator |4 oth | |
| 700 | 1 | |a van der Steeg, Lideke |e investigator |4 oth | |
| 700 | 1 | |a Janssens, Geert |e investigator |4 oth | |
| 700 | 1 | |a van Santen, Hanneke |e investigator |4 oth | |
| 700 | 1 | |a Veening, Margreet |e investigator |4 oth | |
| 700 | 1 | |a den Hartogh, Jaap |e investigator |4 oth | |
| 700 | 1 | |a Pluijm, Saskia |e investigator |4 oth | |
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| 700 | 1 | |a Schellekens, Anke |e investigator |4 oth | |
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