Gas chromatography properties and mass spectrometry fragmentation of anabolic androgenic steroids in doping control
Aim: This study aimed to investigate the gas chromatographic properties and mass spectrometric fragmentations of anabolic androgenic steroids (AASs) after trimethylsilylated derivatization. Materials & methods: A total of 113 AASs were analyzed through gas chromatography-mass spectrometry in the full-scan mode. Results: New fragmentation pathways yielding m/z 129, 143 and 169 ions were analyzed. Based on the characteristics of the A-ring, seven classes of drugs were identified and analyzed. Conclusion: The fragmentation pathway of a new classification of 4-en-3-hydroxyl was reported for the first time. The relationship between the chemical structures of AASs and their retention time, along with their molecular ion peak abundance, was also reported herein for the first time.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Bioanalysis - 15(2023), 12 vom: 11. Juni, Seite 661-671 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Yihao [VerfasserIn] |
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| Links: |
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| Themen: |
Anabolic Agents |
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| Anmerkungen: |
Date Completed 01.08.2023 Date Revised 01.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/bio-2023-0009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359328164 |
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| 245 | 1 | 0 | |a Gas chromatography properties and mass spectrometry fragmentation of anabolic androgenic steroids in doping control |
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| 500 | |a Date Revised 01.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: This study aimed to investigate the gas chromatographic properties and mass spectrometric fragmentations of anabolic androgenic steroids (AASs) after trimethylsilylated derivatization. Materials & methods: A total of 113 AASs were analyzed through gas chromatography-mass spectrometry in the full-scan mode. Results: New fragmentation pathways yielding m/z 129, 143 and 169 ions were analyzed. Based on the characteristics of the A-ring, seven classes of drugs were identified and analyzed. Conclusion: The fragmentation pathway of a new classification of 4-en-3-hydroxyl was reported for the first time. The relationship between the chemical structures of AASs and their retention time, along with their molecular ion peak abundance, was also reported herein for the first time | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a GC–MS | |
| 650 | 4 | |a anabolic androgenic steroids | |
| 650 | 4 | |a characteristic fragment ions | |
| 650 | 4 | |a doping control | |
| 650 | 4 | |a fragmentation pattern | |
| 650 | 4 | |a retention time | |
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| 650 | 7 | |a Anabolic Agents |2 NLM | |
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| 700 | 1 | |a He, Genye |e verfasserin |4 aut | |
| 700 | 1 | |a Sheng, Linghui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yongsheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Youxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Jianghai |e verfasserin |4 aut | |
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