Demographic Traits, Clinical Status, and Comorbidities of Patients With Thromboangiitis Obliterans in Japan
BACKGROUND: The latest demographics, clinical and living conditions, and comorbidities of patients with thromboangiitis obliterans (TAO) in Japan are unknown.Methods and Results: We conducted a retrospective cross-sectional survey using the annual database of the Japanese Ministry of Health, Labour and Welfare medical support system for patients with TAO between April 2013 and March 2014. This study included 3,220 patients (87.6% male), with current age ≥60 years in 2,155 patients (66.9%), including 306 (9.5%) patients aged ≥80 years. Overall, 546 (17.0%) had undergone extremity amputation. The median interval from onset to amputation was 3 years. Compared with never smokers (n=400), 2,715 patients with a smoking history had a higher amputation rate (17.7% vs. 13.0%, P=0.02, odds ratio [OR]=1.437, 95% confidence interval [CI]=1.058-1.953). A lower proportion of workers and students was seen among patients after amputation than among amputation-free patients (37.9% vs. 53.0%, P<0.0001, OR=0.542, 95% CI=0.449-0.654). Comorbidities, including arteriosclerosis-related diseases, were found even in patients in their 20-30 s.
CONCLUSIONS: This large survey confirmed that TAO is not a life-threatening but an extremity-threatening disease that threatens patients' professional lives. Smoking history worsens patients' condition and extremity prognosis. Long-term total health support is required, including care of extremities and arteriosclerosis-related diseases, social life support, and smoking cessation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:88 |
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| Enthalten in: |
Circulation journal : official journal of the Japanese Circulation Society - 88(2024), 3 vom: 22. Feb., Seite 319-328 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Watanabe, Yoshiko [VerfasserIn] |
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| Links: |
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| Themen: |
Buerger’s disease |
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| Anmerkungen: |
Date Completed 23.02.2024 Date Revised 23.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1253/circj.CJ-23-0211 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359248047 |
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| 100 | 1 | |a Watanabe, Yoshiko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Demographic Traits, Clinical Status, and Comorbidities of Patients With Thromboangiitis Obliterans in Japan |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The latest demographics, clinical and living conditions, and comorbidities of patients with thromboangiitis obliterans (TAO) in Japan are unknown.Methods and Results: We conducted a retrospective cross-sectional survey using the annual database of the Japanese Ministry of Health, Labour and Welfare medical support system for patients with TAO between April 2013 and March 2014. This study included 3,220 patients (87.6% male), with current age ≥60 years in 2,155 patients (66.9%), including 306 (9.5%) patients aged ≥80 years. Overall, 546 (17.0%) had undergone extremity amputation. The median interval from onset to amputation was 3 years. Compared with never smokers (n=400), 2,715 patients with a smoking history had a higher amputation rate (17.7% vs. 13.0%, P=0.02, odds ratio [OR]=1.437, 95% confidence interval [CI]=1.058-1.953). A lower proportion of workers and students was seen among patients after amputation than among amputation-free patients (37.9% vs. 53.0%, P<0.0001, OR=0.542, 95% CI=0.449-0.654). Comorbidities, including arteriosclerosis-related diseases, were found even in patients in their 20-30 s | ||
| 520 | |a CONCLUSIONS: This large survey confirmed that TAO is not a life-threatening but an extremity-threatening disease that threatens patients' professional lives. Smoking history worsens patients' condition and extremity prognosis. Long-term total health support is required, including care of extremities and arteriosclerosis-related diseases, social life support, and smoking cessation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Buerger’s disease | |
| 650 | 4 | |a Clinical and living conditions | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Patient demographics | |
| 650 | 4 | |a Thromboangiitis obliterans | |
| 700 | 1 | |a Shimizu, Yuuki |e verfasserin |4 aut | |
| 700 | 1 | |a Hashimoto, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Iwahashi, Toru |e verfasserin |4 aut | |
| 700 | 1 | |a Shigematsu, Kunihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakaoka, Yoshikazu |e verfasserin |4 aut | |
| 700 | 1 | |a Harigai, Masayoshi |e verfasserin |4 aut | |
| 700 | 0 | |a Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) |e verfasserin |4 aut | |
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