Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
© 2023. The Author(s)..
The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation. However, efficient delivery of extracellular vesicles to the injured spinal cord, with minimal damage, remains a challenge. Here we present a device for the delivery of extracellular vesicles to treat spinal cord injury. We show that the device incorporating mesenchymal stem cells and porous microneedles enables the delivery of extracellular vesicles. We demonstrate that topical application to the spinal cord lesion beneath the spinal dura, does not damage the lesion. We evaluate the efficacy of our device in a contusive spinal cord injury model and find that it reduces the cavity and scar tissue formation, promotes angiogenesis, and improves survival of nearby tissues and axons. Importantly, the sustained delivery of extracellular vesicles for at least 7 days results in significant functional recovery. Thus, our device provides an efficient and sustained extracellular vesicles delivery platform for spinal cord injury treatment.
| Errataetall: |
ErratumIn: Nat Commun. 2023 Aug 1;14(1):4603. - PMID 37528087 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Nature communications - 14(2023), 1 vom: 07. Juli, Seite 4011 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fang, Ao [VerfasserIn] |
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Date Completed 10.07.2023 Date Revised 18.11.2023 published: Electronic ErratumIn: Nat Commun. 2023 Aug 1;14(1):4603. - PMID 37528087 Citation Status MEDLINE |
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| doi: |
10.1038/s41467-023-39745-2 |
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NLM359209572 |
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| 500 | |a ErratumIn: Nat Commun. 2023 Aug 1;14(1):4603. - PMID 37528087 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation. However, efficient delivery of extracellular vesicles to the injured spinal cord, with minimal damage, remains a challenge. Here we present a device for the delivery of extracellular vesicles to treat spinal cord injury. We show that the device incorporating mesenchymal stem cells and porous microneedles enables the delivery of extracellular vesicles. We demonstrate that topical application to the spinal cord lesion beneath the spinal dura, does not damage the lesion. We evaluate the efficacy of our device in a contusive spinal cord injury model and find that it reduces the cavity and scar tissue formation, promotes angiogenesis, and improves survival of nearby tissues and axons. Importantly, the sustained delivery of extracellular vesicles for at least 7 days results in significant functional recovery. Thus, our device provides an efficient and sustained extracellular vesicles delivery platform for spinal cord injury treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Wang, Yifan |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Naiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zuo, Yanming |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Lingmin |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Binjie |e verfasserin |4 aut | |
| 700 | 1 | |a Mo, Aisheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yile |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Xurong |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Wanxiong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xiangfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Jingjia |e verfasserin |4 aut | |
| 700 | 1 | |a Abdelrahman, Zeinab |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaodan |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Hanyu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Zhonghan |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Shuang |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Kan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Xiaosong |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xuhua |e verfasserin |4 aut | |
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