Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal
Copyright © 2023 Elsevier Ltd. All rights reserved..
Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:427 |
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| Enthalten in: |
Food chemistry - 427(2023) vom: 30. Nov., Seite 136684 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cianciosi, Danila [VerfasserIn] |
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| Links: |
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| Themen: |
5-Fluorouracil |
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| Anmerkungen: |
Date Completed 24.07.2023 Date Revised 24.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.foodchem.2023.136684 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Cancer stem cells | |
| 650 | 4 | |a Chemoresistance | |
| 650 | 4 | |a Colon cancer | |
| 650 | 4 | |a Manuka honey | |
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| 700 | 1 | |a Zhang, Di |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez López, Nohora Milena |e verfasserin |4 aut | |
| 700 | 1 | |a Briones Urbano, Mercedes |e verfasserin |4 aut | |
| 700 | 1 | |a Quiles, José L |e verfasserin |4 aut | |
| 700 | 1 | |a Amici, Adolfo |e verfasserin |4 aut | |
| 700 | 1 | |a Battino, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Giampieri, Francesca |e verfasserin |4 aut | |
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