Peripheral nailfold capillary microscopic abnormalities in rheumatoid arthritis are associated with arterial stiffness : Results from a cross-sectional study
Copyright © 2023 Elsevier Inc. All rights reserved..
Vascular injury eventually resulting in the establishment of cardiovascular disease is a serious complication in rheumatoid arthritis (RA). Nailfold videocapillaroscopy (NVC) is a non-invasive imaging modality that enables the quantitative and qualitative assessment of the peripheral microvasculature. Nevertheless, capillaroscopic patterns remain inadequately defined in RA, especially regarding their clinical significance as potential markers of systemic vascular impairment. Consecutive RA patients underwent NVC using a standardized protocol, to assess the following parameters: capillary density, avascular areas, capillary dimensions, microhemorrhages, subpapillary venous plexus, and presence of ramified, bushy, crossed and tortuous capillaries. Carotid-femoral pulse wave velocity (PWV) and pulse pressure were measured as well-acknowledged markers of large artery stiffening. The vast majority of our cohort (n = 44) presented a combination of non-specific and abnormal capillaroscopic parameters. Capillary ramification was associated with both PWV and pulse pressure, even after adjustment for cardiovascular risk factors and systemic inflammation. Our study highlights the high prevalence of a wide range of capillaroscopic deviations from the normal patterns in RA. Furthermore, it provides for the first time evidence of an association between structural disorders of the microcirculation and markers of macrovascular dysfunction, suggesting that NVC might have a role as an index of generalised vascular impairment in RA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:150 |
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| Enthalten in: |
Microvascular research - 150(2023) vom: 05. Nov., Seite 104576 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Angeloudi, Elena [VerfasserIn] |
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| Links: |
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| Themen: |
Arterial stiffness |
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| Anmerkungen: |
Date Completed 13.09.2023 Date Revised 17.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.mvr.2023.104576 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359154700 |
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| 100 | 1 | |a Angeloudi, Elena |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Peripheral nailfold capillary microscopic abnormalities in rheumatoid arthritis are associated with arterial stiffness |b Results from a cross-sectional study |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Vascular injury eventually resulting in the establishment of cardiovascular disease is a serious complication in rheumatoid arthritis (RA). Nailfold videocapillaroscopy (NVC) is a non-invasive imaging modality that enables the quantitative and qualitative assessment of the peripheral microvasculature. Nevertheless, capillaroscopic patterns remain inadequately defined in RA, especially regarding their clinical significance as potential markers of systemic vascular impairment. Consecutive RA patients underwent NVC using a standardized protocol, to assess the following parameters: capillary density, avascular areas, capillary dimensions, microhemorrhages, subpapillary venous plexus, and presence of ramified, bushy, crossed and tortuous capillaries. Carotid-femoral pulse wave velocity (PWV) and pulse pressure were measured as well-acknowledged markers of large artery stiffening. The vast majority of our cohort (n = 44) presented a combination of non-specific and abnormal capillaroscopic parameters. Capillary ramification was associated with both PWV and pulse pressure, even after adjustment for cardiovascular risk factors and systemic inflammation. Our study highlights the high prevalence of a wide range of capillaroscopic deviations from the normal patterns in RA. Furthermore, it provides for the first time evidence of an association between structural disorders of the microcirculation and markers of macrovascular dysfunction, suggesting that NVC might have a role as an index of generalised vascular impairment in RA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Arterial stiffness | |
| 650 | 4 | |a Microvascular dysfunction | |
| 650 | 4 | |a Nailfold videocapillaroscopy | |
| 650 | 4 | |a Pulse wave velocity | |
| 650 | 4 | |a Rheumatoid arthritis | |
| 700 | 1 | |a Anyfanti, Panagiota |e verfasserin |4 aut | |
| 700 | 1 | |a Dara, Athanasia |e verfasserin |4 aut | |
| 700 | 1 | |a Pagkopoulou, Eleni |e verfasserin |4 aut | |
| 700 | 1 | |a Bekiari, Eleni |e verfasserin |4 aut | |
| 700 | 1 | |a Sgouropoulou, Vasiliki |e verfasserin |4 aut | |
| 700 | 1 | |a Garyfallos, Alexandros |e verfasserin |4 aut | |
| 700 | 1 | |a Doumas, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Kitas, George D |e verfasserin |4 aut | |
| 700 | 1 | |a Dimitroulas, Theodoros |e verfasserin |4 aut | |
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