The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients : a prospective observational cohort study
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
The role of CD3+CD56+ natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown. In this prospective observational cohort study, we initially recruited 260 septic patients and eventually analyzed 90 patients, of whom 57 were in the SAE group and 37 were in the non-SAE group. Compared to the non-SAE group, 28-day mortality was significantly increased in the SAE group (33.3% vs. 12.1%, p = 0.026), while the mean fluorescence intensity (MFI) of CD86 in CD3+CD56+ NKT cells was significantly lower (2065.8 (1625.5 ~ 3198.8) vs. 3117.8 (2278.1 ~ 5349), p = 0.007). Multivariate analysis showed that MFI of CD86 in NKT cells, APACHE II score, and serum albumin were independent risk factors for SAE. Furthermore, the Kaplan-Meier survival analysis indicated that the mortality rate was significantly higher in the high-risk group than in the low-risk group (χ2 = 14.779, p < 0.001). This study showed that the decreased expression of CD86 in CD3+CD56+ NKT cells is an independent risk factor of SAE; thus, a prediction model including MFI of CD86 in NKT cells, APACHE II score, and serum albumin can be constructed for diagnosing SAE and predicting prognosis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
|---|---|
| Enthalten in: |
Immunologic research - 71(2023), 6 vom: 05. Dez., Seite 929-940 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen, Sheng-Long [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
CD86 |
|---|
| Anmerkungen: |
Date Completed 24.11.2023 Date Revised 24.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s12026-023-09405-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM359067255 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM359067255 | ||
| 003 | DE-627 | ||
| 005 | 20231226080100.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12026-023-09405-0 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1196.xml |
| 035 | |a (DE-627)NLM359067255 | ||
| 035 | |a (NLM)37405561 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen, Sheng-Long |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients |b a prospective observational cohort study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.11.2023 | ||
| 500 | |a Date Revised 24.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
| 520 | |a The role of CD3+CD56+ natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown. In this prospective observational cohort study, we initially recruited 260 septic patients and eventually analyzed 90 patients, of whom 57 were in the SAE group and 37 were in the non-SAE group. Compared to the non-SAE group, 28-day mortality was significantly increased in the SAE group (33.3% vs. 12.1%, p = 0.026), while the mean fluorescence intensity (MFI) of CD86 in CD3+CD56+ NKT cells was significantly lower (2065.8 (1625.5 ~ 3198.8) vs. 3117.8 (2278.1 ~ 5349), p = 0.007). Multivariate analysis showed that MFI of CD86 in NKT cells, APACHE II score, and serum albumin were independent risk factors for SAE. Furthermore, the Kaplan-Meier survival analysis indicated that the mortality rate was significantly higher in the high-risk group than in the low-risk group (χ2 = 14.779, p < 0.001). This study showed that the decreased expression of CD86 in CD3+CD56+ NKT cells is an independent risk factor of SAE; thus, a prediction model including MFI of CD86 in NKT cells, APACHE II score, and serum albumin can be constructed for diagnosing SAE and predicting prognosis | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CD86 | |
| 650 | 4 | |a Co-signaling molecules | |
| 650 | 4 | |a Natural killer T cells | |
| 650 | 4 | |a Sepsis-associated encephalopathy | |
| 650 | 7 | |a Serum Albumin |2 NLM | |
| 700 | 1 | |a Liu, Xiao-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jun-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Xian, Lu-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xu-Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Kang-Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Tian-Cao |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Guo-Ge |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xin-Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Hong-Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Mao-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Wen-Qiang |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Immunologic research |d 1990 |g 71(2023), 6 vom: 05. Dez., Seite 929-940 |w (DE-627)NLM012678260 |x 1559-0755 |7 nnns |
| 773 | 1 | 8 | |g volume:71 |g year:2023 |g number:6 |g day:05 |g month:12 |g pages:929-940 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12026-023-09405-0 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 71 |j 2023 |e 6 |b 05 |c 12 |h 929-940 | ||