Mammary nodules as incidental findings on chest computed tomography : a retrospective analysis on their frequency and predictive value
© 2023. The Author(s)..
PURPOSE: To evaluate the frequency of mammary nodules as incidental findings on chest CT scans and to determine a correlation between semiological features and mammographic and histopathological outcomes.
METHODS: A total of 42,864 chest CT scans performed on patients with breast-unrelated working diagnoses by the Radiology Department at AOU Maggiore della Carità, between 1st January 2016 and 30th April 2022, were analysed. Sixty-eight patients (3 males and 65 females) with mammary nodule CT detection were selected and subjected to mammography, mammary ultrasound and, eventually, biopsy.
RESULTS: Thirty-five of the 68 patients received a histopathological confirmation of malignancy. According to Pearson's Chi-square test, the CT features most likely associated with BI-RADS 5 following mammography were post-contrast enhancement (p = 0.001), margin irregularity (p = 0.0001), nipple retraction (p = 0.001), skin thickening (p = 0.024), and the presence of structurally atypical lymph nodes suspicious for metastatic involvement (p = 0.0001). The CT features predictive of a biopsy positive for malignancy were post-contrast enhancement (p = 0.0001), margin irregularity (p = 0.0001), and the presence of suspicious lymph nodes (p = 0.011). Finally, 63.4% of patients with a working diagnosis related to cancer were diagnosed with breast cancer.
CONCLUSION: Chest CT incidental findings of mammary nodules had a 0.21% incidence rate. The accurate description of some CT scan features, such as post-contrast enhancement, margin irregularity, nipple retraction, skin thickening and the presence of structurally atypical lymph nodes, may help to establish a radiological suspicion of malignancy, especially if these characteristics are supported by a working diagnosis of cancer.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:128 |
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Enthalten in: |
La Radiologia medica - 128(2023), 8 vom: 04. Aug., Seite 912-921 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Agliata, Maria Francesca [VerfasserIn] |
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Links: |
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Themen: |
Breast cancer |
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Anmerkungen: |
Date Completed 14.07.2023 Date Revised 18.07.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s11547-023-01670-1 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM35903215X |
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100 | 1 | |a Agliata, Maria Francesca |e verfasserin |4 aut | |
245 | 1 | 0 | |a Mammary nodules as incidental findings on chest computed tomography |b a retrospective analysis on their frequency and predictive value |
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500 | |a Citation Status MEDLINE | ||
520 | |a © 2023. The Author(s). | ||
520 | |a PURPOSE: To evaluate the frequency of mammary nodules as incidental findings on chest CT scans and to determine a correlation between semiological features and mammographic and histopathological outcomes | ||
520 | |a METHODS: A total of 42,864 chest CT scans performed on patients with breast-unrelated working diagnoses by the Radiology Department at AOU Maggiore della Carità, between 1st January 2016 and 30th April 2022, were analysed. Sixty-eight patients (3 males and 65 females) with mammary nodule CT detection were selected and subjected to mammography, mammary ultrasound and, eventually, biopsy | ||
520 | |a RESULTS: Thirty-five of the 68 patients received a histopathological confirmation of malignancy. According to Pearson's Chi-square test, the CT features most likely associated with BI-RADS 5 following mammography were post-contrast enhancement (p = 0.001), margin irregularity (p = 0.0001), nipple retraction (p = 0.001), skin thickening (p = 0.024), and the presence of structurally atypical lymph nodes suspicious for metastatic involvement (p = 0.0001). The CT features predictive of a biopsy positive for malignancy were post-contrast enhancement (p = 0.0001), margin irregularity (p = 0.0001), and the presence of suspicious lymph nodes (p = 0.011). Finally, 63.4% of patients with a working diagnosis related to cancer were diagnosed with breast cancer | ||
520 | |a CONCLUSION: Chest CT incidental findings of mammary nodules had a 0.21% incidence rate. The accurate description of some CT scan features, such as post-contrast enhancement, margin irregularity, nipple retraction, skin thickening and the presence of structurally atypical lymph nodes, may help to establish a radiological suspicion of malignancy, especially if these characteristics are supported by a working diagnosis of cancer | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Breast cancer | |
650 | 4 | |a CT scan | |
650 | 4 | |a Incidental findings | |
650 | 4 | |a Mammography | |
700 | 1 | |a Calabrò, Naomi |e verfasserin |4 aut | |
700 | 1 | |a Tricca, Stefano |e verfasserin |4 aut | |
700 | 1 | |a Rampi, Anna Maria |e verfasserin |4 aut | |
700 | 1 | |a Gambaro, Anna Clelia Lucia |e verfasserin |4 aut | |
700 | 1 | |a Ferrante, Daniela |e verfasserin |4 aut | |
700 | 1 | |a Carriero, Alessandro |e verfasserin |4 aut | |
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