A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicity of replication-incompetent type-2 adenoviruses carrying African swine fever virus (ASFV) antigens, namely CP204L (p30), E183L (p54), EP402R (CD2v), B646L (p72), and B602L (p72 chaperone). A vaccine cocktail delivered by simultaneous intramuscular (IM) and intranasal (IN) administration robustly elicited both systemic and mucosal immune responses against AFSV in mice and swine and provided highly effective protection against the circulating ASFV strain in farmed pigs. This multi-antigen cocktail vaccine was well tolerated in the vaccinated animals. No significant interference among antigens was observed. The combined IM and IN vaccination using this adenovirus-vectored antigen cocktail vaccine warrants further evaluation for providing safe and effective protection against ASFV infection and transmission.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Emerging microbes & infections - 12(2023), 2 vom: 19. Dez., Seite 2233643 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Wenming [VerfasserIn] |
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| Links: |
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| Themen: |
Adenovirus |
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| Anmerkungen: |
Date Completed 17.07.2023 Date Revised 18.07.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/22221751.2023.2233643 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM359030246 |
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| 520 | |a African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicity of replication-incompetent type-2 adenoviruses carrying African swine fever virus (ASFV) antigens, namely CP204L (p30), E183L (p54), EP402R (CD2v), B646L (p72), and B602L (p72 chaperone). A vaccine cocktail delivered by simultaneous intramuscular (IM) and intranasal (IN) administration robustly elicited both systemic and mucosal immune responses against AFSV in mice and swine and provided highly effective protection against the circulating ASFV strain in farmed pigs. This multi-antigen cocktail vaccine was well tolerated in the vaccinated animals. No significant interference among antigens was observed. The combined IM and IN vaccination using this adenovirus-vectored antigen cocktail vaccine warrants further evaluation for providing safe and effective protection against ASFV infection and transmission | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Liu, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Tianxing |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Chenchen |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Si |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Liqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Liangxue |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Ziyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xinwen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Pingchao |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Suhua |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ling |e verfasserin |4 aut | |
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