The impact of preoperative waiting time in Stage II-III gastric or gastroesophageal junction cancer : A population-based cohort study
© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd..
BACKGROUND: Gastrectomy remains the curative option in gastric cancer. However, the growing concern that preoperative waiting jeopardizes survival has not been fully addressed. The present population-based cohort study aimed to clarify the impact of preoperative waiting time (PreWT).
METHODS: We included patients with clinical Stage II-III gastric cancer who received curative surgery from 2008 to 2017 of Taiwan Cancer Registry. PreWT was defined as the time from endoscopic diagnosis to surgery. The prognostic impact on overall survival (OS) was evaluated with Cox and restricted cubic spline regressions.
RESULTS: A total of 3059 patients with a median age of 68 years were evaluated. The median PreWT was 16 days (interquartile range, 11-24 days), and patients with a shorter PreWT were younger, had a more advanced disease and received adjuvant therapies. Despite a shorter OS occurring with prolonged PreWT (median OS by PreWT [days]: 7-13, 2.7 years; 14-20, 3.1 years; 21-27, 3.0 years; 28-34, 4.7 years; 35-31, 3.7 years; 42-48, 3.4 years; 49-118, 2.8 years; p = 0.029), the differences were not significant after adjustment. The Cox and restricted cubic spline regressions showed that prolonged PreWT was not a significant prognostic factor for OS (p = 0.719).
CONCLUSIONS: The population-based study suggests that a PreWT of 49-118 days does not independently correlate with a poor prognosis in Stage II-III gastric cancer. The study provides rationale for a window period for preoperative therapies and patient optimization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Cancer medicine - 12(2023), 16 vom: 01. Aug., Seite 16906-16917 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yen, Chih-Chieh [VerfasserIn] |
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| Links: |
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| Themen: |
Gastric cancer |
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| Anmerkungen: |
Date Completed 15.09.2023 Date Revised 16.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cam4.6320 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM359025951 |
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| 100 | 1 | |a Yen, Chih-Chieh |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The impact of preoperative waiting time in Stage II-III gastric or gastroesophageal junction cancer |b A population-based cohort study |
| 264 | 1 | |c 2023 | |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Gastrectomy remains the curative option in gastric cancer. However, the growing concern that preoperative waiting jeopardizes survival has not been fully addressed. The present population-based cohort study aimed to clarify the impact of preoperative waiting time (PreWT) | ||
| 520 | |a METHODS: We included patients with clinical Stage II-III gastric cancer who received curative surgery from 2008 to 2017 of Taiwan Cancer Registry. PreWT was defined as the time from endoscopic diagnosis to surgery. The prognostic impact on overall survival (OS) was evaluated with Cox and restricted cubic spline regressions | ||
| 520 | |a RESULTS: A total of 3059 patients with a median age of 68 years were evaluated. The median PreWT was 16 days (interquartile range, 11-24 days), and patients with a shorter PreWT were younger, had a more advanced disease and received adjuvant therapies. Despite a shorter OS occurring with prolonged PreWT (median OS by PreWT [days]: 7-13, 2.7 years; 14-20, 3.1 years; 21-27, 3.0 years; 28-34, 4.7 years; 35-31, 3.7 years; 42-48, 3.4 years; 49-118, 2.8 years; p = 0.029), the differences were not significant after adjustment. The Cox and restricted cubic spline regressions showed that prolonged PreWT was not a significant prognostic factor for OS (p = 0.719) | ||
| 520 | |a CONCLUSIONS: The population-based study suggests that a PreWT of 49-118 days does not independently correlate with a poor prognosis in Stage II-III gastric cancer. The study provides rationale for a window period for preoperative therapies and patient optimization | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a gastric cancer | |
| 650 | 4 | |a gastroesophageal junction cancer | |
| 650 | 4 | |a preoperative waiting time | |
| 700 | 1 | |a Yang, Yi-Hsin |e verfasserin |4 aut | |
| 700 | 1 | |a Ku, Hsiu-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Huang-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Lo, Su-Shun |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Hung-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Chao, Yee |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jen-Shi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Hsiu-Po |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Tsang-En |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Li-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Ming-Shiang |e verfasserin |4 aut | |
| 700 | 1 | |a Yen, Chia-Jui |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Li-Tzong |e verfasserin |4 aut | |
| 700 | 1 | |a Shan, Yan-Shen |e verfasserin |4 aut | |
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