SARS-CoV-2 and the spike protein in endotheliopathy
Copyright © 2023 Elsevier Ltd. All rights reserved..
SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial compartment in the upper and lower airways. There is evidence that the microvasculature in both the pulmonary and extrapulmonary systems is a major target of SARS-CoV-2. Consistent with this, vascular dysfunction and thrombosis are the most severe complications in COVID-19. The proinflammatory milieu triggered by the hyperactivation of the immune system by SARS-CoV-2 has been suggested to be the main trigger for endothelial dysfunction during COVID-19. More recently, a rapidly growing number of reports have indicated that SARS-CoV-2 can interact directly with endothelial cells through the spike protein, leading to multiple instances of endothelial dysfunction. Here, we describe all the available findings showing the direct effect of the SARS-CoV-2 spike protein on endothelial cells and offer mechanistic insights into the molecular basis of vascular dysfunction in severe COVID-19.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
---|---|
Enthalten in: |
Trends in microbiology - 32(2024), 1 vom: 28. Jan., Seite 53-67 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Perico, Luca [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 05.01.2024 Date Revised 22.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.tim.2023.06.004 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM358944155 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM358944155 | ||
003 | DE-627 | ||
005 | 20240323000035.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.tim.2023.06.004 |2 doi | |
028 | 5 | 2 | |a pubmed24n1341.xml |
035 | |a (DE-627)NLM358944155 | ||
035 | |a (NLM)37393180 | ||
035 | |a (PII)S0966-842X(23)00189-0 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Perico, Luca |e verfasserin |4 aut | |
245 | 1 | 0 | |a SARS-CoV-2 and the spike protein in endotheliopathy |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 05.01.2024 | ||
500 | |a Date Revised 22.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 Elsevier Ltd. All rights reserved. | ||
520 | |a SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial compartment in the upper and lower airways. There is evidence that the microvasculature in both the pulmonary and extrapulmonary systems is a major target of SARS-CoV-2. Consistent with this, vascular dysfunction and thrombosis are the most severe complications in COVID-19. The proinflammatory milieu triggered by the hyperactivation of the immune system by SARS-CoV-2 has been suggested to be the main trigger for endothelial dysfunction during COVID-19. More recently, a rapidly growing number of reports have indicated that SARS-CoV-2 can interact directly with endothelial cells through the spike protein, leading to multiple instances of endothelial dysfunction. Here, we describe all the available findings showing the direct effect of the SARS-CoV-2 spike protein on endothelial cells and offer mechanistic insights into the molecular basis of vascular dysfunction in severe COVID-19 | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a endothelial dysfunction | |
650 | 4 | |a spike protein | |
650 | 7 | |a spike protein, SARS-CoV-2 |2 NLM | |
650 | 7 | |a Spike Glycoprotein, Coronavirus |2 NLM | |
700 | 1 | |a Benigni, Ariela |e verfasserin |4 aut | |
700 | 1 | |a Remuzzi, Giuseppe |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Trends in microbiology |d 1996 |g 32(2024), 1 vom: 28. Jan., Seite 53-67 |w (DE-627)NLM074876252 |x 1878-4380 |7 nnns |
773 | 1 | 8 | |g volume:32 |g year:2024 |g number:1 |g day:28 |g month:01 |g pages:53-67 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.tim.2023.06.004 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 32 |j 2024 |e 1 |b 28 |c 01 |h 53-67 |